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Studies on age-related changes in senescence accelerated (SAM-P) mice.

Research Project

Project/Area Number 62570160
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionNiigata University

Principal Investigator

MORI Kazuhiro  Faculty of Science, Niigata University, 理学部, 教授 (90025635)

Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1988: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1987: ¥700,000 (Direct Cost: ¥700,000)
KeywordsAgeing / Senescence accelerated mice / Hemopoiesis / Hemopoietic stem cell / 白血球前駆細胞 / SAM-Pマウス(Senescence Accelerated Mouse)
Research Abstract

Senescence accelerated mice (SAM-P) were established by Prof. T. Takeda at Kyoto University.
This study concerns age-related changes in hemopoietic system of SAM-P.
Numbers of hemopoietic stem cells (CFU-S) and granulocyte-macrophage colony-forming cells (GM-CFC) showed a significant decrease in old mice compared to those in young mice. Reportedly non-accelerated mice of the same strain SAM-R), however, also showed an age-related decrease in hemopoietic activity. This forced us to use normal mice of other strains.
No significant changes were observed in normal mice of BDFI and ddy strains in the numbers of hemopoietic stem cells and GM-CFC.
A possibility of age-related decrease in the number of mast cell-progenitors is also under study, since mast cell-progenitors appear to be closely related to CFU-S and since we have establishe an in vitro assay system of the progenitors with a high seeding efficiency which facilitates quantitative evaluation of mast cell progenitor.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Itoh,Katuhiko: Exp.Hematol.17. 145-153 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Itoh,Katuhiko: Leuk.Res.12. 471-478 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Sawada.Hitoshi: Leuk.Res.12. 763-771 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Itoh,Katuhiko: Jpn.J.Cancer Res.79. 931-937 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Sakoda,Hiroto: Exp.Hematol.,in press.(1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hisha-Izumi,Hiroko: Submitted.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 鶴沢正仁 日本生化学会編: "続・生化学実験講産(コロニー増幅因子(CPA)の測定法)" 東京化学同人社, 31-35 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Itoh, Katuhiko: "Reproducible establishment of hemopoietic supportive cell lines from murine bone marrow." Exp. Hematol.17. 145-153 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Itoh, Katuhiko: "Establishment and characterization of a transplantable erythroblastic leukemia in C3H mice." Leuk. Res.12. 471-478 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Sawada, Hitoshi: "Establishment of hemopoietic stimulating factor producing murine leukemia cell lines." Leuk. Res.12. 763-771 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Itoh, Katuhiko: "Stromal cell-dependent growth of leukemic cells from murine erythroblastic leukemia." Jpn. J. Cancer Res.79. 931-937 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hisha-Izumi, Hiroko: "Age-related decrease in the numbers of hemopoietic stem cells and progenitors in senescence accelerated (SAM-P) mice."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Tsuruwawa, Masahito: Assay of colony promoting activity (CPA).Tokyo Kagaku Dojin-Sha, (Tokyo Association of Chemists)., 31-35 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Itoh,Katuhiko: Exp.Hematol.17. 145-153 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Itoh,Katuhiko: Leuk.Res.12. 471-478 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Sawada,Hitoshi: Leuk.Res.12. 763-771 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Itoh,Katuhiko: Jpn.J.Cancer Res.79. 931-937 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Sakoda,Hiroto: Exp.Hematol.,. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Hisha-Izumi,Hiroko: Submitted.

    • Related Report
      1988 Annual Research Report
  • [Publications] 鶴沢正仁(日本生化学会編): "続、生化学実験講座(コロニー増因子(CPA)の測定法)" 東京化学同人社, 31-35 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kirikae, Teruo: Acta Haemotol.JPX. 50. 784-790 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Kirikae, Teruo: Cell Tissue Kinet.20. 89-98 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Konno, Mitsuo: J. Anaesthesia. 1. 29-34 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Tezuka, Hiroaki: Esp. Hematol.

    • Related Report
      1987 Annual Research Report
  • [Publications] Sakoda, Hiroto: Biomedicine.

    • Related Report
      1987 Annual Research Report
  • [Publications] Itoh, Katsuhiko: Leuk. Res.

    • Related Report
      1987 Annual Research Report
  • [Publications] 鶴沢正仁: "続生化学実験講座8血液(上)(コロニー増幅因子(CPA)の測定法)" 東京化学同人社, 476 (1987)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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