| Project/Area Number |
62570219
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Tokai University |
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Principal Investigator |
INOKO Hidetoshi Tokai University School of Medicine, 医学部, 助教授 (10101932)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1988: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1987: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | HLA / Class II Antigen / Transfectant / MLR Activity / PLT Activity / T Antigen Receptor / Gentic Restriction / 遺伝的多型性 / HLA抗原 / リンパ球混合培養 / T抗原レセプター / PLTクローン / L細胞 |
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| Research Abstract |
DR gene products are commonly thought to be involved in the induction of the mixed lymphocyte reaction. However, very little is known about the role of HLA-DQ and -DP antigens in the MLR. In order to clarify the mechanism of HLA recognition by T antigen receptor, we constructed DQ and DP mouse L or human lymphoid transfected cells. These DQ transfectants were found to be efficient in stimulating peripheral blood lymphocyte proliferation under MLR condition. On the other hand, DP transfectants did not show any MLR activity, but become a good target to DP-specific T cell clone (PLT activity). These results suggest the role of the DQ and DP antigens in the immune response, providing a excellent system for investigating the mechanism underlying genetic restriction and T antigen receptor recognizing HLA class II antigens.
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