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Etiological Studies of Motor Neuron Disease ; Regional and Temporal Mortality Trends as Clues

Research Project

Project/Area Number 62570241
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 公衆衛生学
Research InstitutionHokkaido University

Principal Investigator

KONDO Kiyotaro  Hokkaido University, School of Medicine, Professor, 医学部, 教授 (80018366)

Project Period (FY) 1987 – 1989
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1989: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1988: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1987: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsAmyotrophic lateral sclerosis / Motor neuron disease / Epidemiology / Mortality rate / Environmental Factors / Factor analysis / 運動ニューロン疾患 / 地域変動 / 危険要因
Research Abstract

This study analyzes mortality patterns of motor neuron disease (MND) in the entire Japan for 1965-85 utilizing a total of 13,431 death certificates.
1. Temporal Trends of the Adjusted Mortality Rates
The adjusted mortality rates to the 1965 census population declined since 1960 to 1977 in the both sexes when the rate stabilized, indicating the underlying process to MND is rather vividly liable to socioeconomic variables, because such a rapid change could not be attributed to purely genetic or purely natural - environmental variables.
2. Areal Changes of the Standardized Mortality Ratios (SMR)
The standardized mortality ratios (SMR) were calculated by each of 47 prefectures by three periods of years between 1969-73, 1974-78 and 1979-83 and by sex. The decline was more obvious in the both sexes in the prefectures with higher ratios formerly, especially in Wakayama and Mie.
3. Structure of the Mortality Due to MND
Age-specific mortality rate obeyed the Gompertz law (log rate was linear against the age). No obvious cohort effect was observed. Overall mortality patterns due to MND were identical with the pattern due to overall causes of death.

Report

(4 results)
  • 1990 Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 近藤 喜代太郎: "ー筋萎縮性側索硬化症ー疫学と遺伝について" CLINICAL NEUROSCIENCE. 4 No11. 36-38 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 近藤 喜代太郎: "〈神経疾患の疫学〉運動ニュ-ロン疾患" CLINICAL NEUROSCIENCE. 7 No7. 10-11 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 近藤 喜代太郎: "家族性運動ニュ-トン疾患の遺伝的異種性" BRAIN and NERVE. 413. 225-228 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kiyotayo Kondo: "Is risk to motor neuron diseas influenced by the season of birth?" Japan Jounal Human Genet. 34. 243-246 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kiyotaro Kondo,: "Elsevier Science Publishers B.V.(Biomedical Division)Amyotrophic lateral sclertosis" T.Tsubaki and Y.Yase,editors, (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kiyotaro Kondo: "Leigh N,Swash M (eds)Motor Neuron Disease 2.EPIDEMIOLOGY" SpringerーVerlag,Londo, (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kiyotaro kondo: "Epidemiology and Genetics of amyotrophic lateral sclerosis" Clinical Neuroscience. 4-11. 36-38 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kiyotaro Kondo: "Motor Neuron Disease" Clinical Neuroscience. 7-7. 10-11 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kiyotaro Kondo: "Genetic Heterogeneity of Familial Motor Neuron Disease" Brain and Nerve. 41-3. 225-228 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kiyotaro Kondo: "Is risk to motor neuron disease influenced by the season of birth ?" Japan Journal Human Genet,. 34. 243-246 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kiyotaro Kondo: T. Tsubaki and Y. Yase, editors. Elsevier Science Publishers B. V. (Biomedical Division ) Amyotrophic lateral sclerosis, (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kiyotaro Kondo: Springer - Verlag, Londo. Leigh N, Swash M (eds) Motor Neuron Disease 2. Epidemiology, (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 近藤喜代太郎: "-筋萎縮性側索硬化症-疫学と遺伝について" CLINICAL NEUROSCIENCE. 4No11. 36-38 (1986)

    • Related Report
      1989 Annual Research Report
  • [Publications] 近藤喜代太郎: "〈神経疾患の疫学〉運動ニュ-ロン疾患" CLINICAL NEUROSCIENCE. 7No7. 10-11 (1987)

    • Related Report
      1989 Annual Research Report
  • [Publications] 近藤喜代太郎: "家族性運動ニュ-ロン疾患の遺伝的異種性" BRAIN and NERVE. 413. 225-228 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kiyotaro Kondo: "IS RISK TO MOTOR NEURON DISEAS INFLUENCED BY THE SEASON OF BIRTH?" Japan Jounal Human Genet. 34. 243-246 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kiyotaro Kondo,: "Elsevier Science Publishers B.V.(Biomedical Division)Amyotrophic lateral sclertosis" T.Tsubaki and Y.Yase,editors, (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kiyotaro Kondo: "Leigh N,Swash M(eds)Motor Neuron Disease 2.EPIDEMIOLOGY" Springer-Verlag,Londo, (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 近藤喜代太郎: 脳と神経. 41. 225-228 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Kondo: "Amyotrophic Lateral Sclerosis" Excerpta Medical/Amsterdam, 1-393 (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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