| Project/Area Number |
62570250
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
公衆衛生学
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
KISHI Reiko Sapporo Medical College, Dept. of Public Health Assist. Professor, 医学部, 講師 (80112449)
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Tomoko Sapporo Medical College, School of Allied Health Professionals, Professor, 衛生短期大学部, 教授 (80165951)
MIYAKE Hirotsugu Sapporo Med. College, Dept. of Public Health Professor, 医学部, 教授 (20045363)
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| Project Period (FY) |
1987 – 1989
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1989: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1988: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1987: ¥900,000 (Direct Cost: ¥900,000)
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| Keywords | Cildhood cancer / Parental exposure / Occupation / Leukemia / Neuroblastoma / X-ray / Spray paints / Pesticides / Childhoodneoplasm / Leukemia / Neuroplastoma / Etiology / Paretal Occupation / Home exposure / Occupational exposure / Case-Control Study / Childhood neoplasm / Neuroblastoma / Lymphoma / Parental occupation / Occupational exporure / Case-control study / Childhood neoplasma / Leukema, Brain tumor |
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| Research Abstract |
Purpose : The objectives were to assess the hypotheses of preconceptual, prenatal and postnatal environmental factors which were considered as possible etiologic agents for the neoplasms of the precursor cell in childhood.
Methods : Two independently but simultaneously conducted community based case-control studies are designed to examine the risk factors of childhood cancers and to estimate recall bias. Data were obtained by interview with mothers and postal questionnaire with fathers of cases and controls. 123 ALL, 23 AML and 53 Neuroblastoma were identified. Hospital control group were matched sex and age and population control group were matched place of residence, age and sex.
Results : Mothers' X-ray exposure, Benzin use and alcohol intake during pregnancy, fathers' paint exposure before diagnosis had significantly high odds ratios in multivariate analyses of data set of leukemia cases with population control, while pickles intake, Benzin use, exposure to spray pesticide during pregnancy and contact with animals before diagnosis and fathers' chemical exposure at 1 year before pregnancy and pesticide exposure during pregnancy had high odds ratios in data sets of leukemia with hospital control.
Conclusion : The results suggested parental exposure to environmental factors may play an etiologic role in childhood leukemia.
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