Immunogenetical analysis of genes encoding HLA antigens and a growth factor-receptor in autoimmune diseases
| Project/Area Number |
62570275
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | University of Tsukuba |
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Principal Investigator |
MATSUI Yoshiki University of Tsukuba, Institute of Clinical Medicine, Instructor, 臨床医学系, 講師 (80114784)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1988: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1987: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | HLA / antigen quantity / haplotype / growth factor-receptor / genotype / polymorphism / 自己免疫疾患 / BL抗原 / 遺伝子多形性 / c-sis / 血管内皮細胞 / HLA抗原 / リンパ細胞 / 表面抗原量 / Tリンパ球 / 多型性 |
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| Research Abstract |
The findings in the present study are classified into three groups. (1) The quantity of HLA antigens increases within 24-72 hr following activation of T cells, and then decreases. The quantity of the other differentiation antigens does not increase following T cell activation. The increase in HLA-A and -B antigen expression following T cell activation is independently regulated. No correlation between the increase in the antigen expression and HLA type is recognized. (2) Gene expression of an oncogene, c-sis, which encodes a growth factor and show DNA polymorphism, is enhanced by IL-1 and LPS, and is suppressed by interferon- . Correlation between polymorphism of c-sis and autoimmune disease remains to be investigated. (3) We found that there are 3 types in DNA polymorphism for a growth factor-receptor (BL antigen) in normal controls. One of the types is not recognized in patients with SLE, and the other hand it is increased in patients with RA. Some types of DNA polymorphism different from that in controls are recognized in patients with IDDM.Wwe postulate genetic associations of the BL antigen gene with autoimmune diseases.
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Report
(3 results)
Research Products
(5 results)
