| Project/Area Number |
62570283
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | First Department of Medicine, Teikyo University School of Medicine (1988)
Hamamatsu University School of Medicine (1987) |
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Principal Investigator |
NAGASE Mitsumasa First Department of Medicine, Teikyo University School of Medicine (Professor), 医学部, 教授 (00010124)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Shuzo First Department of Medicine, Hamamatsu University school of Medicine (Instructo, 第一内科, 助手 (60195782)
小林 修三 浜松医科大学, 第一内科, 助手 (63570288)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1988: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1987: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | 免疫複合体 / ダウノマイシン / 糸球体蛋白透過性 / 蛋白尿 / アポフェリチン / SLE / ループス腎炎 |
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| Research Abstract |
An investigation was performed to show whether an alteration of permselectivity of glomerular capillary wall (GCW) per se may influence the distribution of immune complex (IC) in the development of experimental ic nephritis. Apoferritin was used to induce IC nephritis in mice. To alter the permselectivity of GCW, daunomycin was injected to mice prior to the immunization with apoferritin. The results were compared between the animals in which apoferritin alone was given and those in which daunomycin and apoferritin were administered. In the former animals, the IgG and C_3 distribution was confined to mesangial area, thile the latter showed IgG and C_3 not only in mesangial area but also along the capillary wall.
As expected, daunomycin administration induced increased urinary IgG and albumin excretion reflecting the enhanced macromolecular permselectivity in GCW. However, an alteration of antibody production or that of affinity of IC was not noted, which may be a factor other than the macromolecular permelectivity of GCW per se, responsible for the alteration of IC distribution. The findings suggest that charge of GCW per se can induce the althration of IC distribution in glomeruli, and may provide a clue for the future development of effective therapy for glomerulonephritis.
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