| Project/Area Number |
62570293
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | Yokohama City University |
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Principal Investigator |
TANI Kenji Yokohama City Univ. 1st Dep. of Int. Med. Medical Saff., 第一内科, 助手 (20094310)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIGATSUBO Yoshiaki Yokohama City Univ. 1st Dep. of Int. Med. Medical staff., 第一内科, 助手 (40137039)
OKUDA Kenji Yokohama City Univ. Bacteriology Professor, 細菌学, 教授 (40124862)
OKUBO Takao Yokohama City Univ. 1st Dep. of Int. Med. Professor., 第一内科, 教授 (40006705)
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| Project Period (FY) |
1987 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1989: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | histamine receptor / H_1 receptor / H_2 receptor / H_1receptor / H_2receptro / ヒスタミン / H_1レセプター / P388D_1 / J774 / J111 / BW5147 |
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| Research Abstract |
Results of this project were as following ; (1) Macrophage cell line (P388D_1, J744, J111) had two H_1 receptors which had different affinity, (2) T cell line (BW5147) has also two H_1 receptors which had different affinity and receptor number from those of macrophage cell line, (3) H_1 stimulation (Histamine + H_2 antagonist) stimulated cell proliferation, but H_2 stimulation (Histamine + H_1 antagonist) inhibited it.
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