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Study on IgA-specific switch T cells in patients with IgA nephropathy.

Research Project

Project/Area Number 62570300
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 内科学一般
Research InstitutionTokai University

Principal Investigator

SAKAI Hideto  School of Medicine, Tokai University, Department of Internal Medicine, Professor, 医学部・内科, 教授 (80102846)

Co-Investigator(Kenkyū-buntansha) SUGA Takao  School of Medicine, Tokai University, Department of Internal Medicine, Instructo, 医学部・内科, 助手 (50187621)
ENDO Masayuki  School of Medicine, Tokai University, Department of Internal Medicine, Assistant, 医学部・内科, 講師 (10147134)
Project Period (FY) 1987 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1988: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1987: ¥900,000 (Direct Cost: ¥900,000)
KeywordsIgA nephropathy / Switch T cells / CD4 / IgA / IgA産生能亢進 / 家族性免疫異常 / T_<α4>細胞 / IgA産生 / IgA産生亢進 / ヘルパーT細胞
Research Abstract

Enumeration and functional analysis of CD4^+ T cells with receptors for the Fc portion of IgA (i.e. Talpha4 cells) in the peripheral blood or patients with IgA nephropathy, their relatives and age-matched controls were performed to elucidate polyclonal activation of IgA production in this disease. Enumeration of Talpha4 cells was performed by a fluorescence activated cell sorter, and functional analysis was carried out by separation of Talpha4 cells, and IgM-, IgA- and IgG-bearing lymphocytes using panning methods followed by cultures of these cells for 7 days with pokewecd mitogen. There was a significant increase in the amount of peripheral blood Talpha4 cells in patients with IgA nephropathy and their relatives. Talpha4 cells specifically enhanced the switch of IgM-bearing cells to IgA-bearing cells, and this switch activity was inhibited by addition or human myeloma IgA. It is suggested that Talpha4 cells may be responsible for polyclonal activation of IgA production in IgA nephropathy.

Report

(4 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Sakai,H.: "Cellular immunoregulatory aspects of IgA nephropathy" Amer.J.Kiney Dis.12. 430-432 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakai,H.,Miyazaki,M.,Endo,M.and Nomoto,Y.: "Increase of IgA-specific switch T cells in patients with IgA nephropathy" Clin.Exp.Immunol.78. 378-382 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakai,H.(分担執筆): "Recent Studies of IgA Nephropathy in Japan" Nishimura Co.,Ltd./Smith-Gordon and Co.,Ltd., 21 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakai,H.(分担執筆): "International Yearbook of Nephrology 1989" Kluwer Academic Publishers, 24 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakai, H.: "Cellular immunoregulatory aspects of IgA nephropathy." Amer. J. Kidney Dis. 12:430-432, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakai, H., Miyazaki, M., Endo, M. and Nomoto, Y.: "Increase of IgA-specific switch T cells in patients with IgA nephropathy." Clin. Exp. Immunol. 78:378-382, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakai, H.: Immunology of IgA nephropathy. In: Arakawa, M. and Geiyo, F., eds., Recent Studies of IgA Nephropathy in Japan.Nishimura Co., Ltd/Smith-Gordon and Co., Ltd., Niigata and London, 67-87 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakai, H.: IgA Nephropathy. Current views on pathogenesis and treatment. In: Andreucci, V.E., ed., International Yearbook of Nephrology 1989. Kluwer Academic Publishers, Boston, Dordrecht and London, 23-46 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakai,H: "Cellular immunoregulatory aspects of IgA nephropathy" Amer.J.Kiney Dis. 12. 430-432 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sakai H.Miyazaki M.Endo M.and Nomoto Y: "Increase of IgA-specific switch T cells in Patients with IgA nephropathy" Clin.Exp.Immunol. 78. 378-382 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sakai H.(分担執筆): "Recent Studies of IgA Nephropathy in Japan" Nishimura Co.,Ltd/Smith-Gordon and Co.,Ltd., 21( ) (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sakai H. (分担執筆): "International Yearkook of Nephrology 1989" Kluwer Academic Publishers, 24( ) (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sakai,H.: In: Clarkson, A.R., ed., IgA Nephropathy,Marthinus Nijhoff Publishing,Boston,Dordrecht and Lancaster. 176-187 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Sakai,H.,Nomoto,Y.,Tomino,Y.,Endoh,M.,Miura,M. and Suga,T.: In: Mestecky,J.,McGhee,J.R.,Bienenstock,J. and Ogra,P.L., eds.,Recent Advances in Mucosal Immunology,Part B,Plenum Publishing Co.,New York. 1507-1514 (1987)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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