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Studies on the etiologic agent and pathogenesis of summer-type hypersensitivity pneumonitis

Research Project

Project/Area Number 62570349
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionKumamoto University

Principal Investigator

ANDO Masayuki  KUMAMOTO UNIVERSITY First Department of Internal Medicine, 医学部, 助教授 (00040204)

Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsSummer-type hypersensitivity pneumonitis / Trichosporon cutaneum / Inhalation challenge test / Sick-house syndrome / HLAタイピング / 夏型過敏症肺臓炎 / 吸収誘発試験 / serotype関連抗原 / トリコスポロン / クタネウム / HLA抗原
Research Abstract

We studied the etiologic agent and pathogenesis of summer-type hypersensitivity pneumonitis (HP). Our results were as follows.
i. Studies on the etiologic agent of summer-type HP When the incidence of fungi in patients' homes were compared with that in homes of control subjects, extensive distribution of trichosporon cutaneum, an arthro-spore forming yeast, war observed in home environments of patients with summer-type HP but not in homes of normal control subjects. The isolated t. cutaneum demonstrated high reactivity to the patients' sera. almost all patients responded to the inhalation challenge with the culture filtrate antigen of t. cutaneum. These results clearly indicate that T. cutaneum is an etiologic agent of summer type HP. HP induced by T. cutaneum is a new disease of HP groups.
ii. Studies on the pathogenesis of summer-type HP. Environmental study revealed that summer-type HP tended to occur in the resident of old wooded houses, and that T. cutaneum grew on old damp wood, floor mats, bed clothes, or budgeriger droppings in their houses during muggy summer season following the rainy season. In other words, summer-type HP in Japan is a sick-house syn-drome. The phenotype of the major histocompatibility complex, loci A, B, C, DR, and DQ, was studied in 66 patients with Japanese summer-type HP induced by T. cutaneum, and the results were compared to those obtained from 472 normal healthy subjects. Our results showed an increase of the frequency of HLA-DQW3 in the patients, suggesting the importance of the host factors for the generation of this disease.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Yoshida,K.;Ando,M.;Sakata,T.;Araki,S.: The Journal of Allergy and Clinical Immunology. 81. 475-483 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Soda,K.;Ando,M.;Sakata,T.;Sugumoto,M.;Nakashima,H.;Araki,S.: Chest. 93. 76-80 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Sakata,T.;Soda,K.;Ando,M.;Shimazu,K.;Araki,S.: The Journal of Clinical and Laboratory Immunology. 25. 191-199 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 荘田恭聖,安藤正幸,坂田哲宣,中嶋博徳,荒木淑郎: 日本胸部疾患学会雑誌. 25. 1096-1101 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 吉田和子,安藤正幸,坂田哲宣,荘田恭聖,荒木淑郎,島津和泰: 日本胸部疾患学会雑誌. 26. 950-956 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ando,M.;Yoshida,K.;Sakata,T.;Soda,K.;Sugimoto,M.;Suga,M.;Nakashima,H.;Araki,S.: "Sarcoidosis and other granulomatous disorders."Environmental and immunologic studies on the causative agent of summer-type hypersensitivity pneumonitis"" Excerpta Medica, 681-684 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yoshida K; Ando M; Sakata T; Araki S.: "Environmental mycological studies on the causative agent of summer-type hypersensitivity pneumonitis" The Journal of Allergy and Clinical Immunology. 81. 475-483 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Soda K; Ando M; Sakata T; Sugimoto M; Nakaahima H; Araki S.: "Clq and C3 in bronchoalveolar lavage fluid from patients with summer-type hypersensitivity pneumonitis" Chest. 93. 76-80 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Sakata T; Soda K; Ando M; Shimazu K; Araki S.: "Experimental hypersensitivity pneumonitis in rabbits induced by Trichosporon cutaneum: Role of local cellular and humoral immune response" The Journal of Clinical and Laboratory Immunology. 25. 191-199 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Soda K; Ando M; Sakata T; Nakashima H; Araki S.: "Functional studies of BAL lymphocytes from patients with summer-type hypersensitivity pneumonitis" Japanese Journal of Thoracic Diseases. 25. 1096-1101 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yoshida K; Ando M; Sakata T; Soda K; Araki S; Shimazu K.: "Home environmental mycological studies in summer-type hyper-sensitivity pneumonitis" Japanese Journal of Thoracic Diseases. 26. 950-956 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Ando M; Yoshida K; Sakata T; Soda K; Sugimoto M; Suga M; Nakashima H; Araki S.: Environmental and immunologic studies on the causative agent of summer-type hypersensitivity pneumonitis. Excerpta Medica, 681-684 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Sakata,T.;Soda,K.;Ando,M.;Shimazu,K;Araki,S.: Journal Clinical Laboratory Immunology. 25. 191-199 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Ando,M.;Hirayama,K.;Soda,K.;Okubo,R.;Araki,S.;Sasazuki,T.: American Review of Respiratory Disease.

    • Related Report
      1988 Annual Research Report
  • [Publications] Yoshida,K.;Ando,M.;Sakata,T.;Araki,S.: Archives Envronmental Health.

    • Related Report
      1988 Annual Research Report
  • [Publications] Ando,M.;Sakata,T.;Yoshida,K.;Araki,S.;Onoue,K.;Shinoda,T.: Journal of Allergy and Clinical Immunology.

    • Related Report
      1988 Annual Research Report
  • [Publications] Yamasaki,H.;Ando,M.;Sakata,T.;Araki,S.;Onoue,K.: American Review of Respiratory Disease.

    • Related Report
      1988 Annual Research Report
  • [Publications] Yoshida K;Ando M;Sakata T and Araki S.: The Journal of Allergy and Clinical Immunology. 81. 475 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Soda K;Ando M;Sakata T;Sugimoto M;Nakashima H: Chest. 93. 76-80 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] 荘田恭聖, 安藤正幸, 吉田和子, 坂田哲宣, 杉本峯晴, 中嶋博徳, 西隆二, 荒木淑郎: 日本胸部疾患学会雑誌. 25. 112-118 (1987)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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