| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1988: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1987: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Research Abstract |
To clear the sympathetic effects, especially _2 effect, on the cardiac hypertrophy and cardiac NE concentration, the rat was forced to swim, and induced the cardiac hypertrophy by ascending aorta stenosis.
The reduction of cardiac NE concentration was remarkable whien the rat could not swim till the target time. The longer it swimed the less of it. At the cardiac hypertrophy by operation, left ventricular weight increased and NE concentration decreased. However, there was no change of it in the plasma, adrenal and kidney. Guanabenz, _2 -stimulant, 10 mg/kg intra peritonealy every day for four weeks reduced the body weight. When its 1 mg/kg used, no reduction of it happened. And Guanabenz 1 mg/kg for four weeks recovered the reduced cardiac NE concentration and decreased the degree of cardiac hypertrophy induced. Tryosine hydroxylase activity decreased when the cardiac hypertrophy was induced.
Sympathetic _2 effect are involved with the cardiac hypertrophy and NE concentration.
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