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Investigation of the pathgenesis of SSPE by use of murine monoclonal antibodies against measles virus polypeptides.

Research Project

Project/Area Number 62570409
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionHokkaido University

Principal Investigator

TOGASHI Takehiro  Hokkaido University School of Medicine, 医学部, 講師 (70001930)

Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1988: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1987: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsMeasles virus / Monoclonal antibody / SSPE / 巨細胞性肺炎
Research Abstract

Murine monoclonal antibodies against measles virus polypeptides - anti HA69K, anti NP60K, anti F40K, anti M 36K - were obtained hybridoma technique which were specifically reacted with intracellular measles virus polypeptides not only by lytic infecton but also by persistent infection.
Using these antibodies, lung tissues of two patients died with measles giant cell pneumonia were specifically stained by immunofluorescent technique.
CSF samples of two patients with SSPE-14 year girl and 8 year boy-were obtained and were analyzed by electrophoretical, immunological and virological methods. High titer measles specific antibodies and oligoclonal IgG bands were detected in these CSF samples but, no virus specific polypeptides in lymphocytes of these CSFs were stained by immunofluorescence using murine monoclonal antibodies.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] 富樫武弘: 小児科/28/1987/1264-1266.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 柴田睦郎: 日本小児科学会雑誌. 91. 3754-3758 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] T.Yohiki.: Archives of Virologyix. 97. 181-196 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Togashi,T.: Progress in Medical Reproductive Immunology. 2. 54-57 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 富樫武弘: 北海道医学雑誌. 63. 338-342 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 富樫武弘: 臨床とウイルス. 16. 270-274 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 富樫武弘 他: "今日の小児治療指針 第7版" 医学書院, 699 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takehiro Togashi: "Atypical EBV infections" Pediatrics of Japan. 28. 1264-1966 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Mutsuo Shibata: "The long term prognosis of HBV carriers in childhood." J. Japan Pediatric Society. 91. 3754-3758 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takashi Yoshiki: "Rat lymphoid cell lines with HTLV-1 production, III. Transmission of HTLV-1 into rats and analysis of cell surface antigens associated with HTLV-1." Archives of Virology. 97. 181-196 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takehiro Togashi: "Mother to infant transmission of blood-born viruses." Progress in Medical Reproductive Immunology. 2. 270-274 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takehiro Togashi: "Several aspects on mother to infant infection of human retroviruses." Hokkaido J. of Medical Science. 63. 338-342 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takehiro Togashi: Today's Therapy in Pediatrics, 7th ed.Igakushoin, 699 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Togashi,T: Progress in Medical Reproductive lmmunology. 2. 54-57 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 柴田睦郎: 小児科診療. 51. 670-674 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 富樫武弘: 北海道医学雑誌. 63. 338-342 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 柴田睦郎: 小児科. 29. 853-859 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 富樫武弘: 臨床とウイルス. 16. 270-274 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 柴田睦郎: 小児内科. 20. 1829-1835 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 富樫 武弘: 北海道医学雑誌. 62. 250-256 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 富樫 武弘: 医学のあゆみ. 142. 565-567 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 富樫 武弘: 小児科. 28. 1264-1266 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 柴田 睦郎: 日本小児科学会雑誌. 91. 3754-3758 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 柴田 睦郎: 臨床薬理. 18. 719-722 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] T.Yoshiki: Archives of Virology. 97. 181-196 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 富樫武弘 他: "今日の小児理療指針 第7版" 医学書院, 699 (1987)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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