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Analysis of regulatory mechanisms of Fc receptor expression on human lymphocytes

Research Project

Project/Area Number 62570423
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionKyoto University

Principal Investigator

MITSUFUMI Mayumi  Lecturer, Faculty of Medicine, Kyoto University, 医学部, 講師 (70135581)

Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1988: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1987: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsIgE receptor / IgE-binding factor / regulation / interferon / atopic disease / CD23 / フォルボールエステル / 調節機構 / マイトジェン
Research Abstract

Regulation of the low affinity LgE receptor (Fc R2/CD23) expression on peripheral mononuclear cells and a human monocytic leukemia cell line U937 was examined. Surface Fc R2(+) cells among human peripheral mononuclear cells were B lymphocytes. T lympho-cytes, when stimulated with mitogens such as PHA, Con A and LPF, secreted factor(s) which induced Fc R2 expression on B lymphocytes. Dexamethasone suppressed the Fc R2 expression. PMA, interferon- (IFN- ), IFN- and 2', 5'-oligoadenylates (2,5-A) increased Fc R2 expression on U937 cells and dexamethasone suppressed it. 2,5-A was suggested to be a mediator of the effect of IFN- but not that of IFN- . The enhancing activity of PMA but not that of IFN- was inhibited by a protein kinase C inhibitor. PMA and IFN- increased the Fc R2 mRNA level in U937 cells but IFN- and 2,5-A did not increase it. Dexamethasone decreased the Fc R2 mRNA expression.
The numbers of Fc R2(+) cells among peripheral blood mononuclear cells and the serum soluble Fc R2 (LgE-binding factor) levels of atopic children younger than 3 years of age were significantly higher than those of non-atopic age-matched control. Such difference was not seen in the older children. The serum LgE levels of atopic children rapidly increased and reached at a plateau around at 3 years of age. The results suggest a close relationship between the activation mechanisms of LgE synthesis and those of Fc R2 expression.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] 金光明: Clin.exp.Immunol.68. 418-426 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 眞弓光文: Clin.exp.Immunol.71. 202-206 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 金光明: Pediatr.Res.24. 254-257 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 眞弓光文: Mollecular Immunol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 金光明: Pediatr.Res.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 田中まゆみ: Cell.Immunol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K.-M. Kim: "Regulation of IgE receptor expression on human peripheral blood lymphocytes by lymphocytosis promoting factor(LPF), lectins and dexamethasone." Clin. exp. Immunol.68. 418-426 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M. Mayumi: "Regulation of Fc receptor expression on a human monoblast cell line U937." Clin. exp. Immunol.71. 202-206 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K.-M. Kim: "IgE receptor-bearing lymphocytes in allergic and non-allergic children." Prdiatr. Res.24. 254-257 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M. Mayumi: "Alpha interferon and 2', 5'-oligoadenylate enhance Fc receptor (CD23) expression on a human monoblast cell line U937." Mollecular Immunol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] K.-M. Kim: "Soluble low affinity Fc receptors for IgE (sFc RII)/IgE-binding factor (IgE-BF) in the serum of allergic and nonallergic children." Pediatr. Res.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 眞弓光文: Clin.exp.Immunol.71. 202-206 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 金光明: Pediatr.Res.24. 254-257 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 眞弓光文: Mollecular Immunol.

    • Related Report
      1988 Annual Research Report
  • [Publications] 金光明: Pediatr.Res.

    • Related Report
      1988 Annual Research Report
  • [Publications] 田中まゆみ: Cell.Immunol.

    • Related Report
      1988 Annual Research Report
  • [Publications] 金光明: Clinical and experimental Immunology. 68. 418-426 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 眞弓光文: Clinical and experimental Immunology. in press.

    • Related Report
      1987 Annual Research Report
  • [Publications] 吉村文秀: American Journal of Haematology. 26. 47-54 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 吉村文秀: European Journal of Haematology. 39. 136-143 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 岩井義隆: Pediatric Research. 21. 285-288 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 岩井義隆: European Journal of Haematology.

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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