| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1988: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Research Abstract |
1. The principal purpose of the present field of study is the treatment and prognosis of children with school refusal thus, as the initial clinical study, the effect of treatment with anti-depressant medication in these children at our clinic was studied. The subject of the study consisted of 47 children with school refusal in whom the detail of the treatment as well as the prognosis was well documented. In the group receiving amitriptyline, clomipramine.levomepromazine, sulpyride, the school refusal improved 53% whereas in the group not treated with medication, 60% improved. However, since the study was not a prospective controlled one, the possibility of only those children with more severe condition illness were treated with antidepressant cannot be denied.
2. As an attempt to experimentally substantiate the effectiveness of tricyclic antidepressant treatment as a chronotherapy in children with school refusal, we are currently conducting a series of experiments on rats. In one of the
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experiments currently in progress, light-dark cycle is experimentally altered and the rapidity in which the rats obtain reentrainment has been measured. Up to the present time, no significant difference has been observed between the controlled rats and those treated with desipramine, imipramine, and clomipramine.
3. In the previous study, we have demonstrated that circadian rhythm of various clinical parameters are disturbed in children with school refusal. In the present study therefore, the relationship between such disturbance and the prognosis was studied. In terms of circadian rhythm of urine sodium excretion, nocturnal deep body temperature and pulse rate, there was no difference in prognosis between the group in which the abnormality was initially present and in those where it was absent. In term of circadian rhythm of beta-Endorphin level, there was a significant correlation between the presence or absence of the circadian and the immediate prognosis. However, when long term prognosis was studied such correlation was absent. The number of the cases studied was rather small and further detailed evaluation is needed. Less
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