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Microangiographic Study on the relationship between Blood Flow Pattern and Cardiovascular Morphogenesis in the Early Chick Embryo

Research Project

Project/Area Number 62570443
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionTokyo Women's Medical College

Principal Investigator

NISHIBATAKE Makoto  Associate, Tokyo Women's Medical College, 医学部, 助手 (90192252)

Co-Investigator(Kenkyū-buntansha) TOMITA Hitoshi  Associate, Tokyo Women's Medical College (90201657)
IKEDA Kazuo  Associate, Tokyo Women's Medical College (10168122)
TAKAOI Atsuyoshi  Professor, Tokyo Women's Medical College (70075167)
NAKAZAWA Makoto  Associate Professor, Tokyo Women's Medical College (10075567)
TOMITA Sachiko  Associate, Tokyo Women's Medical College (10159171)
全 勇  東京女子医大, 医学部, 助手 (00138885)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1988: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1987: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsEmbryonic blood flow pattern / Flow molding theory / Laminar flow / Spiral blood flow Embryonic Cardiac Contraction pattern / 胎生期心収縮パターン / 弁様機能 / 高速度ビデオ撮影装置 / ラセン血流 / 微小血管造影法 / ラセン状血流 / 中隔形成
Research Abstract

It has been generally accepted that early embryonic hemodynamics greatly contribute to the cardiovascular morphogenesis. Using microangiography in the chick embryo, we studied blood flow pattern in the early embryonic stages. In the first year of the project, intracardiac streams of blue dye injected into peripheral vitelline veins were recorded by 35mm microscopic camera on the color slide films. Multiple laminar flows, which made clockwise spiral fashion in their direction, were recognized before septation of the outflow tract. In the later stages, those multiple spiral flows increased the degree of spirals and tended to be divided into two major flows, right and left heart flow, in parallel with the development of truncoconal ridges. In the second year of the project, high-speed video recording system was applied to confirm the results obtained during the first year. Moreover, we analyzed the relationship between cardiac cycle and cardiac contraction pattern. We also analyzed how the presumptive atrioventricular and semilunar valve regions establish their valve-like function in the early stages. As a model for abnormal cardiovascular morphogenesis, cardiac neural crest-ablated embryos were used in this microangiographic study because preliminary study induced high incidence of cardiovascular malformations with similar procedure.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report

Research Products

(14 results)

All Other

All Publications (14 results)

  • [Publications] 富田斉、中沢誠、西畠信、池田和男、高尾篤良: 日本小児循環器学会雑誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 西畠信、中沢誠、富田斉、池田和男、安井寛、高尾篤良: 日本小児循環器学会雑誌 (第8回小児心機能血行動態談話会報告).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M.Nishibatake,;M.Nakazawa,;S.Mitazawa,;M.L.Kirby: Circulation. 76. Suppl.IV551 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] M.Nishibatake,;M.Nakazawa,;H.Tomita,;K.Ikeda,;A.Takao: Teratology. 38. 517 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hitoshi Tomita; Makoto Nakazawa; Makoto Nishibatake; Kazuo Ikeda; Atsuyoshi Takao: "Changes in Cardiac Volume Induced by Isoproteranol in the Chick Embryo" Acta Cardiologica Paediatrica Japon ica.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Makoto Nishibatake; Makoto Nakazawa; Hitoshi Tomita; Kazuo Ikeda; Hiroshi Yasui; Atsuyoshi Takao: "Development of the Atrium, the Primitive Ventricle and Truncus Arteriosus as Contraction Units in the Early Stages of Chick Embryo" Acta Cardiologica Paediatrica Japonica.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Makoto Nishibatake; Makoto Nakazawa; Sachiko Miyagawa; Atsuyoshi Takao; Margaret L. Kirby: "Microangiographic Analysis of Blood Flow Pattern during Early Cardiovascular Morphogenesis of the Chick Embryo"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Makoto Nishibatake; Makoto Nakazawa; Sachiko Miyagawa; Margaret L. Kirby: "MIcroangiographic Analysis of Blood Flow Pattern during Early Cardiovascular Morphogenesis of the Chick Embryo" Circulation. 76. 551 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Makoto Nishibatake; Makoto Nakazawa; Hitoshi Tomita; Kazuo Ikeda; Atsuyoshi Takao: "High-speed Videographic Analysis of Cardiac Contraction in Ealy Stages of the Chick Embryo" Teratology. 38. 517 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 富田斉、中沢誠、西畠信、高尾篤良: 日本小児循環器学会雑誌.

    • Related Report
      1988 Annual Research Report
  • [Publications] 西畠信、中沢誠、富田斉、池田和男、安井寛、高尾篤良: 日本小児循環器学会雑誌(第8回小児心機能血行動態談話会抄録欄).

    • Related Report
      1988 Annual Research Report
  • [Publications] M.Nishibatake・;M.Nakazawa・;H.Tomita・;K.Ikeda・;A.Takao: Teratology. 38. 517 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Nishibatake,N.,Nakazawa M.,Niyagawa,S.,Kirby M.L.: Circulation. 76. SUPPLE.4-551 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 西畠 信.中沢 誠.安藤 正彦.高尾 篤良.宮川 幸子.Margarct C. Kcrby: 日本小児循環器学会雑誌. 3. 67 (1987)

    • Related Report
      1987 Annual Research Report

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Published: 1987-03-31   Modified: 2018-02-02  

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