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Studies on the pathogenesis and treatment of congenital and acquired circumscribed cutaneous hypomelanosis

Research Project

Project/Area Number 62570459
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionOsaka City University Medical School

Principal Investigator

HAMADA Toshio  Osaka City University Medical School, Professor, 医学部, 教授 (80046870)

Co-Investigator(Kenkyū-buntansha) 寺尾 祐一  大阪市立大学, 医学部, 助手 (40163901)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1988: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1987: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywordsleukoderma centrifugum acquisitum / Sutton's leukoderma / halo congenital nevus / nevus depigmentosus / piebaldism / nevus depigmentosus / まだら症 / piebaldism / 皮膚色素脱失症 / まだら症?piebaldism
Research Abstract

Ultrastructural studies of halo congenital nevus were performed. Histopathological features of the pigmented plaque were compound nevus. No significant inflammatory response was present in the dermis. Electron microscopic findings showed melanocytes in halo epidermis decreased in number. In the remaining melanocytes, normal melanosomes decreased and a number of spherical and granular abnormal melanosomes were observed. Langerhans cells in the basal layer of halo epidermis increased and were frequently in contact with lymphocytes. Some nevus cells in the basal layer of epidermis showed pyknotic nuclei and vacuolated cytoplasm. In the dermis, no degenerated nevus cells were observed. Langerhans cells on the epidermis overlying the nevus considerably increased in number and were seen in contact with several nevus cells. They contained nemerous Langerhans granules, lysosomes phagocytosed melanosomes and many vacuoles due to the enlargement of endoplasmic reticulum. Although inflammatory reaction was scarcely observed in halo congenital nevus, these ultrastructural findings suggested a relationship to some type of immunological mechanism for the degeneration of epidermal nevus cells.
In the hypomelanotic skin of piebaldism, electron microscopy revealed that considerable number of melanocytes were stage II to III and formed melanosome conplex in the dendrites. However, there were no melanosomes in the surrounding keratinocytes. The melanocyte-keratinocyte transfer of melanosomes seemed to be impaired. In the another area of hypomelanotic skin, there were no melanocytes and increased indeterminate calls. In the islands of pigmentation within hypomelanotic skin, spherical or irregular in shape and partially melanized melanosomes, and also ellipsoidal lamellar normally melanized melanosomes were observed.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report

Research Products

(20 results)

All Other

All Publications (20 results)

  • [Publications] 濱田稔夫: 綜合臨床. 36. 915-919 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 濱田稔夫: Mebio. 5. 32-34 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Fukai,K.;et al.: Acta Dermato-Venereology(Stockholm).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 深井和既知 他: 発表予定.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 濱田稔夫: "皮膚疾患最新の治療'87〜'88"尋常性白斑"" 南江堂, 217-218 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 北島淳一: "皮膚臨床電顕アトラス Vol.1"サットン後天性遠心性白斑"" 講談社, 38-39 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 濱田稔夫: "皮膚科専門医テキスト"色素脱失症"" 南江堂,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 濱田稔夫: "皮膚科検査法ハンドブック"白い斑を生ずる疾患(尋常性白斑)を中心に"" 南江堂,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hamada, T.: "Pigmentabnormality in general medicine" Sohgoh-Rinshoh. 36. 915-919 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hamada, T.: "Hypomelanosis: Internal diseases with skin manifestations" Mebio. 5. 32-34 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Fukai, K.; Hamada, T.; Ishii, M.; Kitajima, J.; Terao, Y.: "Acquired pigmented macules in human piebald lesions: Ultrastructure of melanocytes in hypomelanotic skin" Acta Dermato-Venereology (Stockholm).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Kitajima, J.; Ishii, M.; Hamada, T.: Leukoderma centrifugum acquisitum (Sutton), Electron Microscopy in Clinical Dermatology, Vol. 1. Kohdansha, 38-39 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 濱田稔夫: Mebio. 5. 32-34 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Fukai,K.,et al.: Acta Dermato-Venereology.

    • Related Report
      1988 Annual Research Report
  • [Publications] 北島淳一 他: "皮膚臨床電顕アトラスVol.1"サットン後天性遠心性白斑"" 講談社, 38-39 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 濱田稔夫: "皮膚科検査法ハンドブック"白い斑を生ずる疾患(尋常性白斑を中心に)"" 南江堂,

    • Related Report
      1988 Annual Research Report
  • [Publications] 北島淳一 他: 日本皮膚科学会雑誌. 97. 545-553 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 濱田稔夫: 綜合臨床. 36. 915-919 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 濱田稔夫 他: "「皮膚疾患最新の治療'87〜'88」"尋常性白斑"" 株式会社南江堂, 217-218 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 濱田稔夫 他: "「皮膚科専門医テキスト」"色素脱失症"" 株式会社南江堂,

    • Related Report
      1987 Annual Research Report

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Published: 1987-03-31   Modified: 2016-04-21  

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