| Project/Area Number |
62570473
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
SAKO Masao Kobe University, School of Med., Associate Prof., 医学部・付属病院, 助教授 (60030970)
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| Co-Investigator(Kenkyū-buntansha) |
HASE Mamoru Kobe University, School of Med., Assistant, 医学部・付属病院, 助手 (10198707)
HIROTA Shozo Kobe University, School of Med., Lecturer, 医学部・付属病院, 講師 (20181216)
KONO Michio Kobe University, School of Med., Professor, 医学部, 教授 (60030938)
清水 雅史 神戸大学, 医学部付属病院, 助手 (20196520)
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| Project Period (FY) |
1987 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1989: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1988: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Liver Tumor / Hyperthermic Oncology / Induction Heating / Ferromagnetic Particle / Arterial Embolization / Chemotherapy / Polysaccharide / Fluoroptic Thermometer / 交番磁界 / 温度測定 / 肝癌 / 動注療法 / 徐放効果 / 誘導加熱 / 多糖類溶液 / 磁性体 / 肝細胞癌 / 血管塞栓術 |
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| Research Abstract |
Pure iron particles (ASC-100-29:100 mu) were suspended in tenacious polysaccharide solution (ferro- polysaccharide:FPS) for an agent injectable through a needle or an angiographic catheter. VX2-tumors implanted into the liver of rabbits were submitted to this investigation. Trariscatheter arterial embolization was first done with injection of gelatin sponge powder to the liver tumors. Several days after the embolization, FPS was injected directly into the tumor with subsequent ferromagnetic induction heating (radiofrequency: 5OOkHz,91kW). Temperature measurement was made using fluoroptic thermometer. By 15 minutes heating, tumor temperature elevated up to 43ﾟC, while the temperature of the liver parenchym was below 39ﾟC, indicating, a selective heating of the tumor.
In addition, an anti-cancer agent dissolved in the polysaccharide solution which has been used for FPS showed prolongation of agent release within the tumor after intra-arterial infusion. The results suggested that ferromagnetic embolization which we have already applied to the patients with hepatoma can extend its possibility for a multidisciplinary treatment of hepatoina as chemo-embolo- huyperthermic therapy.
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