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Early changes and pathogenesis of primitive senile plaque

Research Project

Project/Area Number 62570484
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionNiigata University

Principal Investigator

TAKEDA Shigeki (1988)  Niigata University, Brain Research Institute, Research Associate, 脳研究所, 助手 (90134957)

巻渕 隆夫 (1987)  新潟大学, 脳研究所, 助教授 (10092727)

Co-Investigator(Kenkyū-buntansha) IKUTA Fusahiro  Niigata University, Brain Research Institute, Professor, 脳研究所, 教授 (20018592)
武田 茂樹  新潟大学, 脳研究所, 助手 (90134957)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsSenile plaque / Primitive senile plaque / Amyloid / Periodic acid-methenamine silver stain / Senile dementia of Alzheimer type / 老年期痴呆 / 電顕
Research Abstract

1) We have studied the early change of the primitive senile plaque using the serial ultrathin sections stained by periodic acid-methenamine silver (PAM) method. the epoxy-embedded thin section for light-microscopy revealed more delicate details of the amyloid component in the senile plaque. The next ultrathin section for electron-microscopy showed positive silver gains on the amyloid filaments and amyloid-like substance among the neuronal and glial processes. On the other hand, it was difficult to identify primitive senile plaque-like structure only by conventional electron-microscopy without pam stained electron-microscopy. Primitive senile plaque-like structure was composed of neurites, glial processes and pam positive amyloid-like filaments. The last was almost 10nm in diameter and ran sparsely and irregularly between neurites. We consider that they are important ans suggestive findings for the pathogenesis of the primitive senile plaque.
2) We have studied the significance of senile plaque in the autopsied brain using by pam stain. One of many examined cases have characteristic histopathological pictures; (1) Numerous senile plaques and moderate neuronal cell loss in the cerebral cortex, (2) a few neurofibrillary tangles in the hippocampus, and (3) well preserved neuron in the subcortical gray matter.
Recently, terry et al. proposed a new disease concept, "SDAT without neocortical NFT_s". The histopathology of the cerebral cortex in our patient was very similar to those observed in their patients. However, the above authors did not mention any subcortical changes. Tentatively, we classified the present case as denile dementia with numerous neocortical senile plaques and preserved subcortical nuclei. Although we feel that further clinicopathological studies are necessary, the present case appears to be somewhat different from the well known picture of sdat from a neuropathological viewpoint.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (35 results)

All Other

All Publications (35 results)

  • [Publications] 巻渕隆夫: 厚生省特定疾患「遅発性ウイルス感染」調査研究班昭和61年度研究報告書. 411. 110-113 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 巻渕隆夫: 新潟大学脳研究所業績集. 20. 20 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takahashi Hitoshi: Clinical Neuropathology. 6. 271-276 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 武田茂樹: Clinical Neuropathology. 31. 142-152 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Oyanagi Kiyomitsu: Brain Research. 411. 205-211 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Oyanagi Kiyomitsu: Clinical Neuropathology. 6. 71-79 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 武田茂樹: 脳と神経. 39. 1171-1179 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Oyanagi Kiyomitsu: Virchows Archiv A. 412. 215-224 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takeda Shigeki: Acta Neuropathologica. 75. 433-440 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takahashi Hitoshi: Neurology. 38. 1065-1070 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takahashi Hitoshi: Acta Neuropathologica.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 若林孝一: 臨床神経学.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Makifuchi Takao: "Amyloid in primitive senile plaque: Serial PAM electron micrroscopic study" Annual Report of the Slow Virus Infection Research Committee, the Ministry of Health and Welfare of Japan. 411. 110-113 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takahashi Hitoshi: "Progressive supranuclear palsy with limbic system involvement: report of a case with ultrastructural investigation of neurofibrillary tangles in various locations" Clinical Neuropathology. 6. 271-276 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takeda Shigeki: "Myoclonus epilepsy with brown pigment and cerebellar cortical degeneration" Shinkei Kenkyu Shimpo. 31. 142-152 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Oyanagi Kiyomitsu: "Selective involvement of large neurons in the neostriatum of Alzheimer's disease and senile dementia: a morphometric investigation" Brain Research. 411. 205-211 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Oyanagi Kiyomitsu: "A morphometric reevaluation of Huntington's chorea with special reference to the large neurons in the neostriatum" Clinical Neuropathology. 6. 71-79 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takeda Shigeki: "An autopsy case of myoclonus epilepsy associated with ragged-red fibers: (Fukuhara disease)" Brain and Nerve. 39. 1171-1179 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Oyanagi Kiyomitsu: "Cytoarchitectonic investigation on the rat spinal cord following ethylnitrosourea administration at different developmental stages" Virchows Archiv A. 412. 215-224 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takeda Shigeki: "Neuropathology of myoclonus epilepsy associated with ragged-red fibers (Fukuhara's disease)" Acta Neuropathologica. 75. 433-440 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takahashi Hitoshi: "Hereditary dentatorubral-pallidoluysian atrophy: Clinical and pathologic variants in a family" Neurology. 38. 1065-1070 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takahashi Hitoshi: "The occurrence of 15-nm wide straight tubules in the neocorticl neurons in progressive supranuclear palsy" Acta Neuropathologica.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Wakabayashi Koichi: "An autopsy case of senile dementia with numerous neocortical senile plaques and preserved subcortical nuclei" Clinical Neurology.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Takeda,Shigeki: Acta Neuropathologica. 75. 433-440 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Takahashi,Hitoshi: Neurology. 38. 1065-1070 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Takahashi,Hitoshi: Acta Neuropathologica.

    • Related Report
      1988 Annual Research Report
  • [Publications] 若林孝一: 臨床神経学.

    • Related Report
      1988 Annual Research Report
  • [Publications] 巻渕隆夫: 厚生省特定疾患「遅発性ウイルス感染」調査研究斑昭和61年度研究報告書. 110-113 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 巻渕隆夫: 新潟大学脳研究所業績集.

    • Related Report
      1987 Annual Research Report
  • [Publications] Takashi Hitoshi: Clinical Neuropathology. 6. 271-276 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 武田茂樹: 神経進歩. 31. 142-152 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Oyanagi Kiyomitsu: Brain Research. 411. 205-211 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Oyanagi Kiyomitsu: Clinical Neuropathology. 6. 71-79 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 武田茂樹: 脳と神経. 39. 1171-1179 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Oyanagi Kiyomitsu: Virchows Archiv A. 412. 215-224 (1988)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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