| Project/Area Number |
62570487
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Nagoya University |
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Principal Investigator |
TATSURO OHTA Assistant Professor, Nagoya University, School of Medicine, 医学部, 講師 (00109323)
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| Co-Investigator(Kenkyū-buntansha) |
TOSHIHARU NAGATSU Professor, Nagoya University School of Medicine, 医学部, 教授 (40064802)
TAMOTSU OKADA Professor, Nagoya University College of Medical Technology, 医療技術短期大学部, 教授 (00023771)
DAIICHIRO NAKAHARA Assistant Professor, Nagoya University College of Medical Technology, 医療技術短期大学部, 助教授 (80128389)
NORIO KANEDA Assistant Professor, Nagoya University School of Medicine, 医学部, 講師 (00144139)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1988: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1987: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Biopterin / Plasma / Affective disorder / Autidepressant / Micro-dialysis / Striatum / Dopamine / セロトニン / 活性バイオプテリン |
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| Research Abstract |
The movement of the plasma biopterin levels of patients with affective disorders and the effect of the intracerebrally administrated biopterin on the metabolism of neurotransmitter in vivo were investigated.
The total biopterin levels of plasma in patients with affective disorders in the symptomatic phase were elevated significantly as compared with those of normal controls, and the elevation tended to be more pronounced in the hypomanic phase than in the depressive phase. However, the plasma biopterin levels of the patients in remission did not differ from those of the normal controls.
The tetrahydrobiopterin (biological active biopterin) levels of plasma in patients with affective disorders were decreased in the depressive phase and were increased in the hypomanic phase compared with those of normal controls. We speculated that there is some disorder of the metabolism of biopterin in patients with affective disorder.
Intracerebrally administrated bopterin does not affect extracellular levels of dopamine and serotonin metabolism in rat striatum in vivo during measurement by brain micro-dyalysis system.
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