| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1988: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1987: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Research Abstract |
We have investigated the alterations of dopamine uptake sites, histamine H_1 receptors and phencyclidine binding sites in the postmortem brain samples from patients with chronic schizophrenia, using [^3H]GBR-12935, [^3H]mepyramine and [^3H]1-[1-(2-thienyl)cyclohexyl]piperidine ([^3H]TCP) as a respective radioligand.
1. The binding sites for [^3H]GBR-12935, a selective dopamine uptake inhibitor, tended to increase in the putamen of patients with schizophrenia as compared with age-matched control subjects, although the difference between the means was not statistically significant.
2. The binding sites for [^3H]mepyramine, a selective histamine H_1 receptor antagonist, were identified in the human brain, and they were significantly decreased by 35 % in the frontal cortex of patients with schizophrenia.
3. The phencyclidine binding sites labeled by [^3H]TCP, which were considered to be coupled with N-methyl-D-aspartate (NMDA)-sensitive L-glutamate receptors, were shown to be influenced by L-glutamate, glycine and Mg^<2+> in the human brain, as demonstrated in other mammals. There were no significant chenges in the specific [^3H]TCP binding in the frontal cortex or hippocampus of patients with schizophrenia.
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