| Project/Area Number |
62570519
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
内分泌・代謝学
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| Research Institution | University of Teikyo |
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Principal Investigator |
YAMANOUCHI Toshikazu The second department of internal medicine, University of Teikyo, 医学部, 講師 (40191374)
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| Co-Investigator(Kenkyū-buntansha) |
簑田 進 帝京大学, 医学部, 助手
AKAOKA Ieo The second department of internal medicine, University of Teikyo, 医学部, 教授 (00000919)
MINODA Susumu The second department of internal medicine, University of Teikyo
箕田 進 帝京大学, 医学部, 助手
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | 1,5-アンヒドログルシトール / 1-デオキシングルコース / ポリオール、尿糖 / 血糖コントロール / 1,5ーアンヒドログルシトール / 1ーデオキシグルコース / ポリオール / 尿糖 / 1, 5-アンヒドログルシトール / 1-デオキシグルコース / kkマウス |
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| Research Abstract |
1,5-Anhydroglucitol(AG) is a six-carbon monosaccharide with a structure resembling that of glucose, and one of the main polyols in human serum. A low ag concentration in blood has been shown to be associated with diabetes mellitus.
However, little has been known about its metabolism and kinetics partially because of the difficulties in methods of measurement. In this study, we demonstrated that the reduction of plasma AG is mainly due to the accelerated urinary excretion of AG which is coincident with the excretion of glucose in rats. On the other hand, according to the reform of assay methods, we have measured a lot of human samples and elucidated the kinetics of plasma AG.
The degree of the reduction of plasma AG was well correlated with the amount of urinary excretion of AG, and the latter reflected the amount of urinary excretion of glucose irrespective of the kind of agent causing the glucosuria in rats. We also demonstrated that the uptake and catabolism of AG were not very active despite of its all-around distribution in the body. The reabsorption of AG was inhibited by glucose in renal tubule. Thus, the reduction of plasma AG seemed to reflect closely the extent of the glucosuria. In human study, we confirmed that the concentration of plasma AG showed a specific reduction in diabetes mellitus. The level of plasma AG was little affected by various factors, such as endocrine function, liver dysfunction, renal dysfunction, body mass, sex or age. The clinical significance of measurement of plasma AG are discussed in this report.
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