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Basic and Clinical Studies of Regulatory Mechanism of GH Secretion

Research Project

Project/Area Number 62570524
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 内分泌・代謝学
Research InstitutionTokyo Women's Medical College

Principal Investigator

SHIBASAKI Tamotsu  Tokyo Women's Medical College, Department of Medicine, 内科, 講師 (00147399)

Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1988: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1987: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsGrowth hormone / Growth hormone releasing factor / Somatostatin / Insulin tolerance test / Arginine / 分泌調節
Research Abstract

Several provocative tests for GH secretion such as insulin tolerance, 1-dopa, arginine infusion and GRF tests have been used in clinical endocrinology. However, the precise mechanisms of GH secretion are not clear in these tests. The mechanisms were, therefore, investigated in this study. Intravenous (iv) injection of 200ug GRF or 0.1U/kg b.w. regular insulin, oral administration of 500mg 1-dopa or infusion of 30g arginine for 30min was preformed 120min, 120min, 90min, or 105nin, respectively, after iv administration of 200ug GRF. The effect of prior subcutaneous administration of SMS201-995, a long acting somatostatin analog, on GH secretion in each provocative test was examined in the same manner. The secretion of GH in response to 200ug GRF was completely inhibited by the prior administration of 200ug GRF, whereas that induced by insulin, 1-dopa or arginine was not affected by the prior sdministration of GRF. The secretion of GH induced by 1-dopa or arginine was completely inhibited by the prior administration of 50ug SMS201-995, and that induced by GRF was completely inhibited by 100ug SMS201-995. The response of GH secretion to insulin was small but significantly preserved even after administration of 100ug SMS201-995. Taken together with the previous reports that 1-dops elevates plasma GRF levels and arginine has no influence on plasma GRF levels, it is suggested that 1-dops stimulates GH secretion probably by suppression of somatostatin release in addition to stimulation of GRF and that arginine stimulates GH secrtion probably by suppression of somatostatin release. It is also suggested that some factor (s) other than GRF and somatostatin is involved in the mechanism whereby insulin stimulates GH secretion since the effect of insulin still exists in the presence of exogenous GRF or somatostatin.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Shibasaki,T.,et al.: Endocrinol.Japon.34. 31-37 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shibasaki,T.,et al.: Endocrinol.Japon.34. 799-807 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shibasaki,T.,et al.: Life Sci.42. 329-334 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hotta,M.,;Shibasaki,T.,et al.: Life Sci.42. 979-984 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Masuda,A.,;Shibasaki,T., et al.: J.Endocrinol.Invest.11. 297-302 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shibasaki,T.,et al.: Life Sci.44. 431-438 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shibasaki,T.,et al.: "Neuroendocrine control of the hypothalamo-pituitary system.Taniguchi Symposia on Brain Sciences" Japan Scientific Societies Press, 151-157 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shibasaki, T.; Masuda, A.; Imaki, T.; Yamauchi, N.; Demura, H.; Shizume, K.: "Interaction between GRF and somatostatin in regulation of GH secretion" Endocrinol. Japan.34. 31-37 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shibasaki, T.; Hotta, M.; Yamauchi, N.; Masuda, A.; Imaki, T.; Demura, H.; Ling, N.; Shizume, K.: "Desensitization of rat pituitary somatotrophs to growth hormone-releasing factor occurs in vitro." Endocrinol. Japan.34. 799-807 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hotta, M.; Shibasaki, T.; Masuda, A.; Imaki, T.; Sugino, N.; Demura, H.; Ling, N.; Shizume, K.: "Effect of human growth hormone-releasing hormone on GH secretion in Cushing's syndrome and non-endocrine disease patients treated with glucocorticoids" Life Sci.42. 979-984 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Masuda, A.; Shibasaki, T.; Hotta, M.; Suematsu, H.; Shizume, K.: "Study on the mechanism of abnormal growth hormone (GH) secretion in anorexia nervosa: no evidence of involvement of a low somatomedin-C level in the abnormal GH secretion." J. Endocrinol. Invest.11. 297-302 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shibasaki, T.; Masuda, A.; Hotta, M.; Yamauchi, N.; Hizuka, N.; Takano, K.; Demura, H.; Shizume, K.: "Effects of ingestion of glucose on GH and TSH secretion: Evidence for stimu-lation of somatostatin release from the hypothalamus byu acute hyperglycemia in normal man and its impairment in acromegalic patients" Life Sci.44. 431-438 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shibasaki, T.; Masuda, A.; Hotta, M.; Imaki, T.; Yamauchi N.; Kato, Y.; Demura, H.; Shizume, K.: GRF and somatostatin in the regulation of GH secretion. Japan Scientific Societies Press, 151-157 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Masuda,A.;Shibasaki,T.,et al.: J.Endocrinol.Invest.11. 297-302 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Hotta,M.;Shibasaki,T.,et al.: Life Sci.42. 979-984 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Shibasaki,T.,et al.: Life Sci.44. 431-438 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Shibasaki,T.,et al.: "Neuroendocrine control of the hypothalamo-pituitary system.Taniguchi Sympsia on Brain Sciences" Japan Scientific Societies Press, 151-157 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Tamotsu Shibasaki,et al.: Endocrinologia Japonica. 34. 799-807 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Tamotsu Shibasaki, et al.: Life Sciences. 42. 329-334 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Tamotsu Shibasaki,et al: Life Sciences. (1988)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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