| Project/Area Number |
62570542
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | Kyoto University |
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Principal Investigator |
YOSHIDA Yataro Assist. Prof., 1st Div., Dept. Int. Med., Faculty of Medicine, Kyoto Univ., 医学部・内科第一講座, 講師 (80064525)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGISHI Morihisa Professor, Health Care Inst., Shiga University, 保健管理センター, 教授 (50026829)
ITOH Kazuhiko Assist. Prof., Blood Transf. Service, Kyoto Univ. Hospital, 医学部, 講師 (50034640)
UCHINO Haruto Professor, 1st Div., Dept. Int. Med., Faculty of Medicine, Kyoto Univ., 医学部・内科第一講座, 教授 (40034615)
YOSHIDA Yataro Assist. Prof., 1st Div., Dept. Int. Med., Faculty of Medicine, Kyoto Univ. (80064525)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Hemopoietic stem cells / proliferation and differentiation of hemopoietic cells / hemopoietic factors / renal anemia / 不応性貧血 / 前白血病 / 造血刺激因子とレセプター / サイトカイン |
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| Research Abstract |
A. Role of Prostaglandin E_2(PGE_2) in granulopoiesis: The inhibitory effect of PGE_2 on CFUgm was overcome by excess CSF whilst showing little changes in the numbers and/or affinity of CSF receptors. The inhibition by PGE_2 apperars to act through post CSF receptor mechanisms, inbetween intracellular cAMP and c-myc transcription.
B. Erythropoinetin and anemia in chronic renal failure(CRF): Marrow CFUe was markedly increased in CRF. Epo administration resulted in a significant inprovement in anemia. The marrow in CRF appears spurinously normal, incapable to show a compensatory increase in de novo erythropoiesis via a lack of Epo.
C. Studies on myelodysplastic syndromes(MDS): The growth of marrow CFUgm at the time of diagnosis was significantly related to the survival. In addition, requential changes in the CFUgm growth patterns correlated with the different clinical outcome of MDS. Serial in situ observation of individual hemopoietic clones reveals the presence of clones failing to grow continuously in culture or clones showing to degenerate. These abortive clones conceivably represent ineffective hemopoiesis.
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