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Stem cell disorders as observed from proliferation and differentiation of hemopoietic cells

Research Project

Project/Area Number 62570542
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionKyoto University

Principal Investigator

YOSHIDA Yataro  Assist. Prof., 1st Div., Dept. Int. Med., Faculty of Medicine, Kyoto Univ., 医学部・内科第一講座, 講師 (80064525)

Co-Investigator(Kenkyū-buntansha) YAMAGISHI Morihisa  Professor, Health Care Inst., Shiga University, 保健管理センター, 教授 (50026829)
ITOH Kazuhiko  Assist. Prof., Blood Transf. Service, Kyoto Univ. Hospital, 医学部, 講師 (50034640)
UCHINO Haruto  Professor, 1st Div., Dept. Int. Med., Faculty of Medicine, Kyoto Univ., 医学部・内科第一講座, 教授 (40034615)
YOSHIDA Yataro  Assist. Prof., 1st Div., Dept. Int. Med., Faculty of Medicine, Kyoto Univ. (80064525)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
KeywordsHemopoietic stem cells / proliferation and differentiation of hemopoietic cells / hemopoietic factors / renal anemia / 不応性貧血 / 前白血病 / 造血刺激因子とレセプター / サイトカイン
Research Abstract

A. Role of Prostaglandin E_2(PGE_2) in granulopoiesis: The inhibitory effect of PGE_2 on CFUgm was overcome by excess CSF whilst showing little changes in the numbers and/or affinity of CSF receptors. The inhibition by PGE_2 apperars to act through post CSF receptor mechanisms, inbetween intracellular cAMP and c-myc transcription.
B. Erythropoinetin and anemia in chronic renal failure(CRF): Marrow CFUe was markedly increased in CRF. Epo administration resulted in a significant inprovement in anemia. The marrow in CRF appears spurinously normal, incapable to show a compensatory increase in de novo erythropoiesis via a lack of Epo.
C. Studies on myelodysplastic syndromes(MDS): The growth of marrow CFUgm at the time of diagnosis was significantly related to the survival. In addition, requential changes in the CFUgm growth patterns correlated with the different clinical outcome of MDS. Serial in situ observation of individual hemopoietic clones reveals the presence of clones failing to grow continuously in culture or clones showing to degenerate. These abortive clones conceivably represent ineffective hemopoiesis.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Hitoshi Sawada.: Acta Haematologica Japonica. 51. 816-820 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yataro Yoshida.: Acta Haematologica Japonica. 51. 1092-1096 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yataro Yoshida.: Journal of Clinical Pathology. 41. 763-767 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hiroto Sakoda.: Biomedicine and Pharmacotherapy. 42. 335-341 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yataro Yoshida.: Acta Haematologica Japonica. 51. 1448-1454 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Seiichi Ohmori.: Acta Haematologica Japonica. 51. 1558-1564 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Haruto Uhcino.;Fumimaro Takaku.;Yataro Yoshida.: "Myelodysplastic Syndromes Pathophysiology and Treatment" Elsevier, 217 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 吉田弥太郎: "白血病・悪性リンパ腫" 6 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yataro Yoshida: "Erythropoietic Changes in Chronic Hemodialysis Patients Undergoing Recombinant Human Erythropoietin Therapy" Acta Haematologica Japonica. 51. 1092-1096 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yataro Yoshida: "Refractory Myelodysplastic Anaemias with Hypocellular Bone Marrow" Journal of Clinical Pathology. 41. 763-767 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hiroto Sakoda: "Clonal Assay of Mast Cell Progenitors in Semi-solid Culture with a High Seeding Efficiency" Biomedicine and Pharmacotherapy. 42. 335-341 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yataro Yoshida: "Conservative Treatment of Refractory Myelodysplastic Anemias: A Japanese Cooperative Study" Acta Haematologica Japonica. 51. 1448-1454 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Seiichi Ohmori: "The Mechanism of Prostaglandin E_2 Effects on Hemopoietic Progenitor Cells from Human Bone Marrow" Acta Haematologica Japonica. 51. 1558-1564 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hatuto Uchino, Fumimaro Takaku, Yataro Yoshida: Myelodysplastic Syndromes Pathophysiology and Treatment. Elsevier, 217 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Hitoshi Sawada: Acta Haematologica Japonica. 51. 816-820 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yataro Yoshida: Acta Haematologica Japonica. 51. 1092-1096 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yataro Yoshida: Journal of Clinical Pathology. 41. 763-767 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Hiroto Sakoda: Biomedicine and Pharmacotherapy. 42. 335-341 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yataro Yoshida: Acta Haematologica Japonica. 51. 1448-1454 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Seiighi Ohmori: Acta Haematologica Japonica. 51. 1558-1564 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Haruto Uchino;Fumimaro Takaku;Yataro Yoshida: "Myelodysplastic Syndromes Pathophysiology and Treatment" Elsevier, 1-217 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 吉田弥太郎: "白血病・悪性リンパ腫" 南江堂, 173-178 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yataro Yoshida: Acta Haematologica Japonica. 50. 37-45 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Yataro Yoshida: British Journal of Haematology. 65. 119-120 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Yataro Yoshida: International Journal of Cell Cloning. 5. 356-375 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Eiji Kobayashi: Acta Haematologica Japonica. 50. 7-14 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Hitoshi Sawada: Leukemia Research. 10. 1461-1468 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] Shigeru Oguma: Cancer Research. 47. 2196-2198 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 吉田弥太郎: "Myelodyaplastic syndrome/Annual Review" 中外医学社, 16 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 吉田弥太郎: "MDSの臨床的ならびに生物学的特徴/白血病細胞の生物医学的特性とその制御" 癌と化学療法社, 9 (1987)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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