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Pathophisiologic analysis of refractory anemias based on biostatistics.

Research Project

Project/Area Number 62570545
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionKyoto University

Principal Investigator

OGUMA Shigeru  School of Medicine, Kyoto University, Assistant, 医学部, 助手 (00169260)

Co-Investigator(Kenkyū-buntansha) UCHINO Haruto  School of Medicine, Kyoto University, Professor, 医学部, 教授 (40034615)
YOSHIDA Yataro  School of Medicine, Kyoto University, Lecturer, 医学部, 講師 (80064525)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1988)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsRefractory anemia / Prognostic factors / Leukemic transformation / 非白血化死亡 / 白血化フリー生存時間 / 混合指数分布模型 / 相対ハザード
Research Abstract

A computer database of refractory anemia patients was created. This included 90 variables of 499 patients. Product limit estimates of median survival from presentation were, 1,305 days in refractory anemia(RA), 497 days in RA with excess of blasts(RAEB), and 1,791 days in RA with ring sideroblasts(RARS), respectively. Leukemic transformation occured within 3,000 days from presentation. Leukemia-free rates after 3,000 days were, 80% in RA, 32% in RAEB, and 9i% in RARS, respectively. Multivariate Cox's proportional hazards model analysis revealed that 6 variables, i.e., RAEB, abnormal granules in granulocyte series, male, mononuclear large megakaryocytes, age older than 50 years, and promyelocytes in peripheral blood<1%, were risk factors for leukemic transformation. For nonleukemic death, risk factors were, metamyelocytes in peripheral blood>=1%, age older than 50 years, lower hemoglobin level, platelet count<100,000/micro liter, mononuclear large megakaryocytes, and abnormal nucleus in granulocyte series. Parametric exponential mixture model revealed that several proportion of patients have negligible risk to be leukemia, and the probability to be leukemia could be estimated by several variables at presentation.

Report

(3 results)
  • 1988 Annual Research Report   Final Research Report Summary
  • 1987 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Shigeru Oguma.: Cancer Research. 46. 3698-3700 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shigeru Oguma.: Cancer Research. 47. 2196-2198 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shigeru Oguma.: Cancer Research. 47. 3599-3602 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shigeru Oguma.: Acta Haematologica Japonica. 51. 1412-1418 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shigeru Oguma.: Acta Haematologica Japonica.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yataro Yoshida.: Acta Haematologica Japonica. 51. 1448-1454 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yataro Yoshida.: J.Clinical Pathology. 41. 763-767 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Yataro Yoshida.: Acta Haematologica Japonica. 50. 37-45 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 吉田弥太郎: 臨床血液. 27. 1744-1751 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 吉田弥太郎: "新内科学大系「骨髄異形成症候群」" 中山書店, 18 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] 吉田弥太郎: "内科MOOK「不応性貧血」" 金原出版, 15 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shigeru Oguma: "Factors influencing leukemic transformation in refractory anemias with excess of blasts, with ringed sideroblasts, and without ringed sideroblasts." Cancer Research. 46. 3698-3700 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shigeru Oguma: "Varying probability of the development of acute nonlymphoblastic leukemia in refractory anemia patients with an excess of blasts." Cancer Research. 47. 2196-2198 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shigeru Oguma: "Factors influencing nonleukemic death in refractory anemia, refractory anemia with ring sideroblasts, and refractory anemia with excess of blasts." Cancer Research. 47. 3599-3602 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shigeru Oguma: "Prognostic factors in refractory anemias." Acta Haematologica Jpn.51. 1412-1418 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shigeru Oguma: "Prognosis of refractory anemias." Acta Haematologica Jpn.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1988 Final Research Report Summary
  • [Publications] Shigeru Oguma: Cancer Research. 46. 3698-3700 (1986)

    • Related Report
      1988 Annual Research Report
  • [Publications] Shigeru Oguma: Cancer Research. 47. 2196-2198 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Shigeru Oguma: Cancer Research. 47. 3599-3602 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Shigeru Oguma: Acta Haematologica Japonica. 51. 1412-1418 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Shigeru Oguma: Acta Haematologica Japonica.

    • Related Report
      1988 Annual Research Report
  • [Publications] Yataro Yoshida: Acta Haematologica Japonica. 51. 1448-1454 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yataro Yoshida: J.Clinical Pathology. 41. 763-767 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yataro Yoshida: Acta Haematologica Japonica. 50. 37-45 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] 吉田弥太郎: "新内科学大系「骨髄異形成症候群」" 中山書店, 81-98 (1986)

    • Related Report
      1988 Annual Research Report
  • [Publications] 吉田弥太郎: "内科MOOK「不応性貧血」" 金原出版, 134-148 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Shigeru Oguma: Cancer Research. 46. 3698-3700 (1986)

    • Related Report
      1987 Annual Research Report
  • [Publications] Shigeru Oguma: Cancer Research. 47. 2196-2198 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Shigeru Oguma: Cancer Research. 47. 3599-3602 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Shigeru Oguma: Acta Haematologica Japonica.

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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