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Cancer and Amino acid metabolism - Effect of total parenteral nutrition (TPN) with arginine imbalanced solution on the growth of Yoshida sarcoma.

Research Project

Project/Area Number 62570583
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionKansai Medical University

Principal Investigator

HATANO Takehiko  Kansai Medical University, Lecturer, 医学部, 講師 (50077731)

Co-Investigator(Kenkyū-buntansha) ASAO Yasunobu  Kansai Medical University, assistant, 医学部, 助手 (00175829)
NISHI Masaharu  Kansai Medical University, assistant, 医学部, 助手 (90164532)
HIOKI Koshiro  Kansai Medical University, assistant professor, 医学部, 助教授 (60077641)
Project Period (FY) 1987 – 1988
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1988: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
KeywordsCancer / Amino acid metabolism / Arginine imbalance
Research Abstract

The effect of total parenteral nutrition (TPN) with arginine imbalanced solution containing enriched branched chain amino acids(TEO-10) on the growth of Yoshida sarcoma was examined in tumor-bearing Donryu rats.
Arginine contents in TEO-10, and AI-I,II and III were 1,050g/dl, 3,050g/dl, 5,000g/dl, and 7,000g/dl, respectively. The rats were infused for 8 days via TPN route with each arginine imbalanced solution and then sacrificed.
The body weight gain in the AI-II group was better than those in the TEO-10, AI-I and III groups. The tumor growth was also significantly suppressed in the AI-II group.
The arginine and ornithine concentrations in the serum, urine and tumor tissue in the AI groups were significantly higher than that in the TEO-10 group.
These results suggest that TPN with AI-II solution, which is equivalent to 5 % arginine imbalanced solution, has significant inhibitory effects on the growth of Yoshida sarcoma.

Report

(3 results)
  • 1989 Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 畑埜武彦: "アルギニン・インバランス輸液の抗腫瘍効果ーアミノ酸組成配合比について" 日本外科代謝栄養学会誌.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] TAKEHIKO HATANO: "Effect of total parenteral nutition (TPN) with arginine imbalanced solution on the growth of Yoshida sarcoma." under contribution to "The Japanese Journal of Surgical Metabolism and Nutrition".

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 畑埜 武彦: 日本外科代謝栄養学会誌.

    • Related Report
      1988 Annual Research Report
  • [Publications] 畑埜 武彦: 日本外科代謝栄養学会誌.

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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