The prognostic value for flow cytometric DNA analysis in colorectal cancer patients.
| Project/Area Number |
62570602
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Mie University |
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Principal Investigator |
SUZUKI Hiroshi Mie University School of Medicine, Professor, 医学部, 教授 (20004632)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Junji Mie University Hospital, Assistant, 医学部附属病院, 助手 (20144272)
MATSUMOTO Koichi Mie University Hospital, Lecturer, 医学部附属病院, 講師 (80024694)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1988: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1987: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Colorectal Cancer / Flow Cytometry / DNA Ploidy / BrdU / フローサイトメトリー / DNAプロイディー / DNAindex / Proliferative index |
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| Research Abstract |
An association between DNA aneuploidy of tumor cells and a poorer clinical outcome of patients has been recognized in various human solid tumors. The prognostic value of floe cytometry DNA analysis in colorectal cancer patients was investigated. DNA aneuploidy appeared to correlate with more advanced disease and a poorer survival in colorectal cancer patients, but reported results were not always consistent. DNA ploidy as a marker for predicting the survival of colorectal cancer patients should not therefore be viewed in isolation, but should be eveluated in combination with other conventional prognostic variables. The S-phase cell compartment within a tumor appears to be promising as a marker for predicting the survival of colorectal cancer patients, but there remain technical problems in establishing an accurate estimation of the S-phase cell compartment within a tumor by conventional flow cytometry. The application of a bromodeoxyuridine-specific antibody might be as an usual tool for obtaining the accurate flow cytometric estimaiton of the S-phase cell population within a tumor.
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Report
(3 results)
Research Products
(20 results)
