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A CYTOMETRICAL AND NUCLEAR DNA ANALYSIS OF MALIGMANT TUMORS IN CHILDREN -CYTOLOGICAL CHARACTERISTICS AND PROGNOSIS-

Research Project

Project/Area Number 62570623
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionHyogo Medical University

Principal Investigator

TOYOSAKA Akihiro  Hyogo college of medicine, First department of surgery, assistant professor, 医学部, 助教授 (20068498)

Co-Investigator(Kenkyū-buntansha) NOSE Katsuyoshi  Hyogo college of medicine, First department of surgery, assistant, 医学部, 助手 (30189401)
MITSUNOBU Masao  Hyogo college of medicine, First department of surgery, assistant, 医学部, 助手 (70148667)
Project Period (FY) 1987 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1989: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1988: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1987: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsPediatric cancers / Cytomorphological characteristics / Cytometrical analysis / DNA ploidy / Neuroblastoma / 肝芽腫 / 神経芽腫 / ウイルムス腫瘍 / 小児癌の特性 / 小児肝癌 / ウイルス腫瘍
Research Abstract

Seventy-six neuroblastomas, 46 Wilms' tumors, and 36 primary liver carcinomas in children were investigated by quantitative cytologic measurements in resected or autopsy cases, utilizing an image analyzing computer system. The morphology of embryonic tumors in childhood malignancies showed much smaller size in nuclear and cell area, comparatively uniform pattern, and immature morphology rather than undifferentiated one. The nuclear size of tumor cells in pediatric patients was closely correlated with the prognosis, with favorable prognosis in the smaller size group. A striking characteristics in the cancer of children was immature cytomorphologic features that show few deviations from normal fetal or embryonal cells. A large difference between neuroblastoma and the other pediatric tumors was that the former showed much large change in the nuclear size by age. The change of the neuroblastoma cell by aging was suggested to be due to the development of normal ganglion cell itself. Aneuploidy pattern in pediatric tumors showed a better prognosis contrary to adult cancers. Its was suggested that the high sensitivity for chemotherapy in the pediatric tumors, was due to these morphologic features, and that rapid growth of the pediatric tumor was due to the nature of normal fetal or embryonic tissue.

Report

(4 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] 豊坂昭弘: "小児癌の細胞形態学的研究ー小児癌の細胞形態学的特徴と予後ー" 日本外科学会雑誌. 88. 1117-1120 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 豊坂昭弘: "神経芽細胞腫の細胞形態学的研究ーその細胞形態学的特性と予後ー" 小児がん. 24. 41-43 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 豊坂昭弘: "小児肝がん" 臨床と研究. 65. 1832-1840 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Akihiro Toyosaka: "A cytomorphological study of Neuroblastoma -Cytometrical characteristics and prognosis-" The 2Ist Annual Meeting of the Pacific Association of the Pediatric Surgeons(Taipei). (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 豊坂昭弘: "神経芽細胞腫の細胞形態学的研究 その細胞形態学的特性と予後" 第3回日本小児がん研究会(津). (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 藤元治朗: "肝細胞癌の核DNA解析" 日本外科学会雑誌. 90. 1348-1352 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 豊坂昭弘: "小児固型癌の細胞形態学的特性と予後" 第27回日本小児外科学会総会(愛媛). (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Akihiro Toyosaka and Eizo Okamoto: "A CYTOMETARICAL STUDY OF MALIGNANT TUMORS IN CHILDREN -CYTOLOGICAL CHARACTERISTICS AND PROGNOSIS-" Journal of Japan Surgical Society, 88:1117-1120, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Akihiro Toyosaka, Eizo Okamoto, Tatsuo Okasora, Katsuyoshi Nose and Yoshifumi Tomimoto: "A cytomorphological study of neuroblastoma -Cytological characteristics and prognosis-" Pediatric Oncology 24:41-43, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Akihiro Toyosaka and Eizo Okamoto: "Primary liver carcinoma in infancy and childhood" Jap. J. Clin. Exp. Med. 65(6):1832-1840, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Akihiro Toyosaka, Eizo Okamoto, Tatsuo Okasora, Katsuyoshi Nose, Yoshifumi Tomimoto and Toshihiro Muraji: "A cytomorphological study of Neuroblastoma -Cytometrical characteristics and prognosis-" The 21st Annual Meeting of the PAPS (Taipei) April 14, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Akihiro Toyosaka, Eizo Okamoto Tatsuo Okasora, Katsuyoshi Nose and Yoshifumi Tomimoto: "A cytological study of neuroblastoma" The 3 Annual Meeting of the Japanese Pediatric Oncology (Tsu city) November 27, 1987 Presentation (work-shop).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Jiro Fujimoto, Eizo Okamoto, Naoki Yamanaka, Shiro Fujiwara, Toshihiro Kato, Masao Mitsunobu: "Nuclear and Analysis of Hepatocellular Carcinoma" J. Jap. Surg. Soc. 90(9):1348-1352, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Akihiro Toyosaka, Eizo Okamoto, Tatsuo Okasora, Masao Mitsunobu, Katsuyoshi Nose and Yoshifumi Tomimoto: "A cytomorphological characteristics and prognosis of solid pediatric malignancies" J.Jap. Soc. Ped. Surg. April 26, 1990 Presentation(work-shop).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 豊坂昭弘: "小児癌の細胞形態学的研究-小児癌の細胞形態学的特徴と予後-" 日本外科学会雑誌. 88. 1117-1120 (1987)

    • Related Report
      1989 Annual Research Report
  • [Publications] 豊坂昭弘: "神経芽細胞腫の細胞形態学的研究-その細胞形態学的特性と予後-" 小児がん. 24. 41-43 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 豊坂昭弘: "小児肝がん" 臨床と研究. 65. 1832-1840 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Akihiro Toyosaka: "A cytomorphological study of Neuroblastoma-Cytometrical characteristics and prognosis-" The 2Ist Annual Meeting of the Pacific Association of the Pediatric Surgeons(Taipei). (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 豊坂昭弘: "神経芽細胞腫の細胞形態学的研究-その細胞形態学的特性と予後-" 第3回日本小児がん研究会(津). (1987)

    • Related Report
      1989 Annual Research Report
  • [Publications] 藤元治朗: "肝細胞癌の核DNA解析" 日本外科学会雑誌. 90. 1348-1352 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 豊坂昭弘: "第27回日本小児外科学会総会(愛媛)" 小児固型癌の細胞形態学的特性と予後, (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 豊坂昭弘: 日本外科学会会誌. 88. 1117-1120 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] 豊坂昭弘: 小児がん. 24. 41-43 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 豊坂昭弘: 臨床と研究. 65(6). 1832-1840 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Akihiro Toyosaka: 21st Annual Meeting of Pacific Association of Pediatric Surgeous.April 1988.

    • Related Report
      1988 Annual Research Report
  • [Publications] 能勢勝義: 小児がん. 25. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 豊坂 昭弘: 日本外科学会誌. 88. 1117-1120 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 豊坂 昭弘: 小児がん. 23. (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] 豊坂 昭弘: 日小外会誌. 24.

    • Related Report
      1987 Annual Research Report
  • [Publications] AKIHIRO TOYOSAKA: 21st Annual Meeting of Pacific Acsociation of Pediatric Suigeovs , April 1988.

    • Related Report
      1987 Annual Research Report
  • [Publications] Eizo Okamoto,Naoki Yamanaka, Akihiro Toyosaka Nobutaka Tanaka and Kohei Yabuki: Neoplasm of the Liver. Springer-Verlag. 353-365 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 岡本 英三: 第23回 日本肝癌研究会 日本肝臓学会誌.

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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