| Project/Area Number |
62570623
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
TOYOSAKA Akihiro Hyogo college of medicine, First department of surgery, assistant professor, 医学部, 助教授 (20068498)
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| Co-Investigator(Kenkyū-buntansha) |
NOSE Katsuyoshi Hyogo college of medicine, First department of surgery, assistant, 医学部, 助手 (30189401)
MITSUNOBU Masao Hyogo college of medicine, First department of surgery, assistant, 医学部, 助手 (70148667)
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| Project Period (FY) |
1987 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1989: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1988: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1987: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Pediatric cancers / Cytomorphological characteristics / Cytometrical analysis / DNA ploidy / Neuroblastoma / 肝芽腫 / 神経芽腫 / ウイルムス腫瘍 / 小児癌の特性 / 小児肝癌 / ウイルス腫瘍 |
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| Research Abstract |
Seventy-six neuroblastomas, 46 Wilms' tumors, and 36 primary liver carcinomas in children were investigated by quantitative cytologic measurements in resected or autopsy cases, utilizing an image analyzing computer system. The morphology of embryonic tumors in childhood malignancies showed much smaller size in nuclear and cell area, comparatively uniform pattern, and immature morphology rather than undifferentiated one. The nuclear size of tumor cells in pediatric patients was closely correlated with the prognosis, with favorable prognosis in the smaller size group. A striking characteristics in the cancer of children was immature cytomorphologic features that show few deviations from normal fetal or embryonal cells. A large difference between neuroblastoma and the other pediatric tumors was that the former showed much large change in the nuclear size by age. The change of the neuroblastoma cell by aging was suggested to be due to the development of normal ganglion cell itself. Aneuploidy pattern in pediatric tumors showed a better prognosis contrary to adult cancers. Its was suggested that the high sensitivity for chemotherapy in the pediatric tumors, was due to these morphologic features, and that rapid growth of the pediatric tumor was due to the nature of normal fetal or embryonic tissue.
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