A TRIAL OF NEW TECHNIQUE OF VASCULAR ANASTOMOSIS USING GLUTIDE AS AN ABSORBABLE EXTERNAL SPRINT

Research Project

Project/Area Number	62570642
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	Thoracic surgery
Research Institution	JICHI MEDICAL SCHOOL
Principal Investigator	OHARA Tsutomu Jichi Medical Scool, Thorac.& Cardiovasc.Surg.,Assistant, 医学部, 助手 (40152235)
Co-Investigator(Kenkyū-buntansha)	TAKE Akira Jichi Medical Scool, Thorac.& Cardiovasc.Surg.,Assistant, 医学部, 助手 (90192161) FUKUSHIMA Kanae Jichi Medical Scool, Thorac.& Cardiovasc.Surg.,Assist.Professor, 医学部, 助教授 (90049023) HASEGAWA Tsuguo Jichi Medical Scool, Thorac.& Cardiovasc.Surg.,Professor, 医学部, 教授 (30048954)
Project Period (FY)	1987 – 1988
Project Status	Completed (Fiscal Year 1988)
Budget Amount *help	¥1,800,000 (Direct Cost: ¥1,800,000) Fiscal Year 1988: ¥800,000 (Direct Cost: ¥800,000) Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywords	vascular procedure / anastomosis / Glutide / one-knot arastomosis
Research Abstract	After initial foudamental experimentation, vascular anastomosis using glutide copolymer (lactide: glycolide,80:20) as an external splint was undertaken in 24 dogs. The vessel was transected and introduced into a glutide pipe-sprint. The wall of vessel was turned back 180 over the edge of the sprint. This reflected part of the vessel and the glutide were covered with the freed-up distal side of the vessel. The onelknot anastomosis was completed with circular ligature over the vessels. The right carotid arteries in 13 dogs were anstomosed using glutide and the left carotid arteries of the same dogs were anstomosed by hand suture. Another 11 dogs underwent autogenous venousgrafting in jugular vein. The proximal site was anastomosed by the one knot anstomosis and the distal site was anstomosed by hand suture. The patency rate at the anastomosed site was 100%, except initial 2 grafts, confirmed by angiography and/or by autopsy. Light microscopic and scanning electromicroscopicodse vation showed relatively good epitherialization of intima at the anastomotic. This technique is considered to be clinically applicable.