| Project/Area Number |
62570654
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nagoya University School of Medicine |
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Principal Investigator |
TAKAHASHI TATSUO Nagoya University School of Mecicine, 医学部, 助手 (20188022)
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| Co-Investigator(Kenkyū-buntansha) |
服部 和良 名古屋大学, 医学部, 医員
TANAKA TAKAYUKI Nagoya University School of Mecicine, 医学部, 医員
KOBAYASHI TATSUYA Nagoya University School of Mecicine, 医学部, 助教授 (10093030)
HATTORI KAZUTOSHI Nagoya University School of Mecicine
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Argon haser / Argon Dye haser / Photodynamictherapy / Malignant Brain Tumor / Hematoporphyrin Derivatives / T9-gliosarcoma / ラット移植脳腫瘍 / Tq gliosarcoma / J9 gliosarcoma |
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| Research Abstract |
Experimental rat brain tumors implanted 9L gliosarcoma cells were treated intratumorally by Argon Dye Laser with 630 nm wave length followed by 48 hours after intraperitoneal injection of 10 mg/kg HpD. Photoradiation was performed for 15 minutes with power of 150 mW by two different optical fiber tips, which were cylindrical type and flat type.
T9 gliosarcoma implanted rats survived for about 27.5+6.0 days (N=6). Those rats which were intraperitoneously administered by 10 mg/kg HpD survived for 28.4 + 4.8 days (N=20). Those rats which were intraperitoneously administered by 20 mg/ kg body weight survived for 25.7 + 6.2 days(N=18).
Because we thought that 10 m/g kg body weight administratiow^^nould obtain better results than that of 20 mg / kg body weght, we chose 10 mg / kg HpD administration to all the following experiments. Those rats which were photodynamically treated by flat-type optical fiber tip survived for 27.1 + 4.0 days (N=7). In conclusion, there were no apparent effect of photodynamic therapy on survival time, there were some cases whose tumor were necrotized and shrunk by these photodynamic therapy.
The main causes of death were remarkable brain edema and intratumorous hemorrhaes. If it is possible to prevent brain edema and intratumorous hemorrhages, a better result of photodynamic therapy on brain tumors could be obtained.
In addition, those rats which were treated photodynamically by cylindrical type optical fiber tip survived for 17.6 + 9.0 days (N=7).
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