| Project/Area Number |
62570659
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kobe University |
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Principal Investigator |
FUJITA Katsuzo Kobe University Hospital, Assistant Professor, 医学部附属病院, 講師 (60093530)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Satoshi Kobe University school of Medicine, Professor, 医学部, 教授 (10030850)
EBARA Kazumasa Kobe University school of Medicine, Research Associate, 医学部, 助手 (20151996)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1988: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1987: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Cerebral Ischemia / Magnetic Resonance Imaging / Ischemic Edema / 虚血性浮腫 / MRI / 脳梗塞 / 脳血管関門 / 虚血性脳学腫 |
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| Research Abstract |
Experimental and Clinical Studies on Acute Cerebral Ischemia by Magnetic Resonance Imaging
Nuclear magnetic resonance imaging (MRI) was performed in the acute stage of experimental and clinical cerebral ischemia. The time course of MRI, free water component of the ischemic lesion were experimentally examined in rats ischemic model induced by unilateral middle cerebral artery occulsion. The MRI system employed was designed for clinical use and the permanent magnet was operated at a field strength of 0.15 tesla. Free water component in the ischemic lesion was studied by means of differential scanning calorimetry (DSC). The ischemic lesion could be revealed on a T2-weighted image and a T2-calculated image 12 hours after ischemic insult, and on a T1-weighted image and a T1-calculated image 24 hours after ischemic insult. These changes on MRI in experimental ischemia were similar to those in clinical cases of cerebral ischemia. Free water component increased markedly from 12 to 24 hours after insult and this increase was paralleling the change of ischemia on T1-weighted images.
From these results, it is concluded that MRI can detect cerebral ischemia 12 hours after insult on a T2-weighted image and the changes of a T1-weighted image are correlated with free water component of the cerebral ischemia.
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