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Studies on Factors Influencing to Refractory Epilepsy and its Surgical Indications

Research Project

Project/Area Number 62570665
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionKagoshima University

Principal Investigator

ASAKURA Tetsuhiko  Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (30075254)

Co-Investigator(Kenkyū-buntansha) TERADA Kousaku  Kagoshima Univ., Faculty of Medicine, Assistant professor, 医学部, 助手 (00207482)
KASAMO Sizuya  Kagoshima Univ., Faculty of Medicine Univ. Hospital, Assistant professor, 医学部・附属病院, 助手 (60161014)
NIIRO Masaki  Kagoshima Univ., Faculty of Medicine Univ. Hospital, Assistant professor, 医学部・附属病院, 助手 (30172612)
KUSUMOTO Kazuhiro  Kagoshima Univ., Faculty of Medicine Univ. Hospital, Assistant professor, 医学部・附属病院, 講師 (40145488)
KADOTA Koki  Kagoshima Univ., Faculty of Medicine, Subprofessor, 医学部, 助教授 (00094136)
古賀 靖之  鹿児島大学, 医学部附属病院, 助手 (90195701)
妹尾 包人  鹿児島大学, 医学部, 助手 (40163117)
浜田 博文  鹿児島大学, 医学部附属病院, 講師 (80094168)
上津原 甲一  鹿児島大学, 医学部, 助教授 (40094122)
Project Period (FY) 1987 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1989: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1988: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1987: ¥600,000 (Direct Cost: ¥600,000)
KeywordsEpilepsy / Refractory Epilepsy / Surgical Treatment / MRI / MRS / Partial Complex Seizure / Epileptogenic Focus / 外科的治療 / T_2延長 / 海馬萎縮 / 燐代謝低下 / 側頭葉てんかん / 脳波 / X線CT / γCBF / EEG topography / てんかん焦点
Research Abstract

The authors tried to contribute the surgical management on refractory epilepsy through these experiences.
The surgical treatment of epilepsy performed in Japan is almost limited to topectomy and temporal lobectomy. Except for these two methods, sometimes stereotaxic surgery is performed. But transaction, surgical treatment of epilepsy in the real sense of the word, is rarely performed. To decide whether surgical treatment of epilepsy is indicated, preoperative evaluation, whereby the criteria for surgical treatment have to be fully matched, is necessary.
Proper administrative measures are necessary to be taken considering the local financial conditions. The survey shows that the present state is quite unsatisfactory. Therefore at present, these are many important things to be done ranging from the establishment of the operative such as foundation of epileptic centers, spread of information, establishment of a system of co-operative interdisciplinary research.
Magnetic resonance imaging (M … More RI) is a newly adopted technique which may be useful in the investigation of epileptogenic lesions, and it became clear that MRI sometimes shows greater sensitivity in the detection of cryptogenic type than X-ray CT does. Our study suggests that MRI contributes the detection of surgically correctable abnormalities in seizure management.
The authors analyzed patients of refractory epilepsy. And we investigated the factors influencing to refractoriness and also surgical indication. Up to the present, patients who had organic lesions as a source of epilepsy tended to be treated surgically. It is noteworthy that there are a few false refractory in the patients without organic lesions. It is important that false refractory patients should be excluded from surgical indications.
MRI is a new approach which may be useful in the investigation of refractory epilepsy for surgical management, further more, 31P-magnetic resonance spectroscopy (MRS) is expected to be a useful method in the investigation of metabolic change in the epileptic focus. 31P-chemical shift imaging (CSI) was done in 11 epileptic patients, and some abnormality was found in 7 cases out of 11 epilepsies. High energy phosphates and inorganic phosphate (Pi) tend to decrease at the side of EEG focus in patients with organic lesions. Less

Report

(4 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • Research Products

    (38 results)

All Other

All Publications (38 results)

  • [Publications] T.Asakura: "Refractory epilepsy:An opproach from surgery" The Japanese J.of Psychiat.& Neurology. 41. 355-359 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K.Uetsuhara: "A comporative study on EEG patterns rewrded with depth and scalp electrodes in patients with brain tumor" The Japanese J.of Psychiat.& Neurology. 41. 606-608 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 朝倉哲彦: "Magnetic resonance imagingによる診断の問題点と治療の進歩" 脳と神経. 40. 451-459 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 朝倉哲彦: "我が国におけるてんかん外科治療の現況-アンケ-ト調査より-" Neurosurgeons. 8. 362-369 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Asakura: "Chairmans Notes, The role of neuroimaging in the Clinical Practice of epilepsy, with a special reference to the conlative studies on the epileptogenic foci." Folia Psychiatrica et Nearologica Japonica. 43(3). 401-402 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 朝倉哲彦: "特集MRIの進歩-読影に必要な新しい撮像法Chemical Shift Imaging" 画像診断. 9. 942-952 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 朝倉哲彦: "要説脳神経外科" 発達疫学研究出版部(水戸市), 358 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 朝倉哲彦: "脳神経外科シリ-ズ(高倉公朋監修)機能的脳神経外科" 現代医療社, 182 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Asakura, M. Gondo, K. Uetsuhara, T. Mihara, K. Matsuda and T. Tottori: "Refractory epilepsy; An approach from surgery." Folia Psychiatrica et Neurologica Japonica. 41(3). 355-359 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K. Uetsuhara, T. Asakura and M. Gondo: "A comparative study on EEG patterns recorded with depth and scalp electrodes in patients with brain tumor." Folia Psychiatrica et Neurologica Japonica, 41(3):606-608, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Asakura, K. Uetsuhara: "Advances in diagnostic and therapeutic applications of magnetic resonance imaging for CNS lesions." Brain and Nerve. 40:451-459, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Asakura, K. Nakamura, M. Gondo, K. Uetsuhara: "The present Situation of the surgical treatment of epilepsy in Japan -From the results of the investigation with questionnaire-." Neurosurgeons 8:362-369, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Asakura & K. Watanabe: "Chairman's Note. The role of neuroimagimg in the clinical practice of epilepsy. -with a special reference to the correlative studies on the epileptogenic foci." Folia Psychiatrica et Neurologica Japonica, 43(3): 401-402.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Asakura, M. Sasahira, K. Uchimura, A. Okada, T. Fujimoto, T. Miyazaki, J. Hasegawa, N. Iriguchi: "Chemical shift imaging." J. Medical Imaging. 9(8):942-952, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Asakura: Giude-line. Neurosurgery.Hattatsuekigaku kenkyu-sya(Mito), (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Asakura: Neuroimaging of epplepsy. Functional neurosurgery. Series of neurosurgery. Gendaiiryou-sya 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Asakura: "Chairman's Notes.The role of neuroimaging in the clinical practice of epilepsy.-With a special reference to the correlatiore studies on the epileptogente foci" Folia Psychiatrica of Neunilogica Japonica. 43. 401-402 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 朝倉哲彦: "てんかん最前線(16)第22回日本てんかん学会報告(2)シンポジウム「てんかん臨床における画像診断の役割」を編成司会して" 波(日本てんかん協会). 13. 132-135 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 朝倉哲彦: "特殊MRIの進歩-読影に必要な新しい撮像法 Chemical Shoft Imaging" 画像診断. 9. 942-952 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 朝倉哲彦: "特集:てんかん-最近の進歩-19:外科治療" 小児内科. 22. 121-127 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 朝倉哲彦: "目で見る脳波 局在性脳疾患と脳波1.Low grade gtoma" 臨床脳波. 32. 50-54 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 朝倉哲彦: "目で見る脳波 局在性脳疾患と脳波2.High grade gtona" 臨床脳波. 32. 121-125 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 朝倉哲彦: "要説 脳神経外科" 発達疫学研究出版部(水戸市), (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 朝倉哲彦: "脳神経外科シリ-ズ(高倉公朋監修)機能的脳神経外科" 現代医療社, (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 朝倉哲彦: クリニカル・ニューロサイエンス. 5. 448-449 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Uetsuhara,K.;Asakura,T.;et al.: Japanese J.psychiat & Neurol. 40. 433-435 (1986)

    • Related Report
      1988 Annual Research Report
  • [Publications] Asakura,T.;et al.: Japanese J.psychiat & Neurol. 41. 355-359 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] 朝倉哲彦: 日本てんかん協会月刊機関紙「波」. 11. 364-371 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] 春園明宏、朝倉哲彦 他: 脳神経外科. 16. 603-606 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Uetsuhara,K.;Asakura,T.: Japanese J.psychiat & Neurol. 43. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 朝倉哲彦: "牧豊編小児神経外科の進歩と展望てんかん-病態と外科治療" にゅーろん社, 417-431 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 朝倉哲彦: "高倉公朋監修機能脳神経外科てんかん外科の進歩-画像診断について" 現代医療社, (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 朝倉哲彦: CLINICAL NEUROSCIENCE. Vol. 5(No. 4). (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] K. Uetsuhara;T. Asakura;K. Hirohara;M. Gondo and H. Oda: Acta Medica Univ Kagashima. 29(2). 153-160 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 朝倉哲彦: ブレインナーシンブ. 3(10). 45-55 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 朝倉哲彦: 波. 1987-11. 2-9 45-55 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] K. Uetsuhara;T. Asakura;M. Gondo: The Japanese Journal of psychiatry and Neurology. 41(3). 606-608 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] T. Asakura;K. Uetsuhara;M. Gondo;T. Mihara;K. Natsuda;T. Tottori: The Japanese Journal of psychiatry and Neurology. 41(2). 355-359 (1987)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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