| Project/Area Number |
62570694
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | KEIO UNIVERSITY |
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Principal Investigator |
HIRABAYASHI Kiyoshi KEIO UNIVERSITY SCHOOL OF MEDICINE, 医学部整形外科, 助教授 (60051413)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAYAMA Nobuyuki KEIO UNIVERSITY SCHOOL OF MEDICINE, 医学部整形外科, 助手 (70164473)
KOYANAGI Takahiro KEIO UNIVERSITY SCHOOL OF MEDICINE, 医学部整形外科, 助手 (90162073)
ICHIMURA Shouichi KEIO UNIVERSITY SCHOOL OF MEDICINE, 医学部整形外科, 助手 (00159849)
若野 紘一 慶應義塾大学, 医学部整形外科, 講師 (80051655)
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| Project Period (FY) |
1986 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Biomechanics / Chemonucleolysis / Viscoelasticity / Chymopapain / Collagenase / 動的粘弾性 / 振動工学 / ケモヌクレオリーシス / 椎体固定 / ハイドロキシアパタイト / キクパパイン |
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| Research Abstract |
To study the mechanical properties of enzyme-injected intervertebral discs, quasi-static compression tests and dynamic vibration tests were performed on canine intervertebral discs 2weeks after enzyme injection (short-period group) and within 6 months (long-period group) respectively, and the findings in each group were compared with those of normal discs as a control.
The results of the quasi-static tests were as follows:in the short-period group, normalized stiffness of the discs was reduced significantly and the normalized creep rate was increased. The intradiscal pressures produced by external loading in short-period discs were almost half those of the control.in the long-period group such values tended to recover partially.
The results of the dynamic tests were as follows:in the sort- period group,both elasticity and viscosity were reduced,while in the long-period group elasticity recovered but viscosity did not. These findings suggest that the shock-absorbing ability of enzyme-injected discs does not recover.
Then, hydroxyapatite were inserted into the discs after collagenase injection to examine the possibility of ossification of the discs. But ossification could not be proved.
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