| Project/Area Number |
62570712
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
麻酔学
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| Research Institution | KAWASAKI MEDICAL SCHOOL |
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Principal Investigator |
SAKAI Takayuki KAWASAKI MEDICAL SCHOOL, ASSOCIATE PROFESSOR OF ANESTHESIOLOGY AND INTENSIVE CARE UNIT, 麻酔科集中治療部 (30069067)
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| Co-Investigator(Kenkyū-buntansha) |
IUCHI Iwao KAWASAKI MEDICAL SCHOOL, PROFESSOR OF BIOCHEMISTRY, 生化 学, 教授 (40068979)
FUKUI Akira KAWASAKI MEDICAL SCHOOL, RESIDENT OF ANESTHESIOLOGY, 麻酔 科, 助手 (50189924)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1988: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1987: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | Halothane / Biodegradation / Urinary fluoride excretion / 胆汁中弗素排泄 / 吸入麻酔薬 / 弗素 / 代謝 |
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| Research Abstract |
Fluoride excretions in urine and bile were measured for 10 days after 3 hours of 1% halothane anesthesia in dogs whose stomach, intestine and omentum had been removed surgically. The weight of the removed organs was corresponded to only 7% of the body weight. Nevertheless, an amount of halothane absorbed was reduced by 19% compared to that in the control group. While urinary fluoride excretion was reduced by 58% compared to that in the control group, biliary fluoride excretion in bile did not differ from that in the control.
From the above results, an important role of the splanchnic organs, especially the adipose tissues, on the biodegradation of halothane was clearly realized and the degradated substance excreted in the bile might be supposed to be not similar with that in urine.
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