| Project/Area Number |
62570747
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yamanashi Medical School |
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Principal Investigator |
YASUMIZU Takehiko Associated Professor, Yamanashi Medical School, 医学部, 助教授 (80107705)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1988: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Angiogenesis factor / growth factor / placental bed / 胎盤 / 卵巣 / DHAS負荷テスト / DHAS半減期 / 胎盤絨毛組織 |
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| Research Abstract |
Rapid neovasculaization (angiogenesis) takes place in the placental bed of the uterus and the placenta during pregnancy. Whereas the structural components of uterine and placental angiogenesis have been studied extensively, the mechanisms by which these new blood vessels arise are still poorly understood. In this study, I have employed in vitro assay to investigate whether these tissues possess growth and angiogenesis activities. The results demonstrate the presence of factors that stimulate prolieration of mouse BALB/C 3T3 cells and cultured bovine capillary endothelial cells. These actieties are present in extracts of myometrium, placental bed and placenta of the pregnant rat as well as human placenta.
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