| Project/Area Number |
62570782
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Nara Medical University |
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Principal Investigator |
MATSUNAGA Takashi Nara Medical Univ. ENT Depart., Professor, 医学部, 教授 (10028475)
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| Co-Investigator(Kenkyū-buntansha) |
SONODA Fumiko Nara Medical Univ. ENT Depart., assistant doctor, 医学部, 助手 (00211326)
KASHIWAGI Noriko Nara Medical Univ. ENT Depart., assistant doctor, 医学部, 助手 (80152635)
KITAOKU Yoshiyuki Nara Medical Univ. ENT Depart., assistant doctor, 医学部, 助手 (40161468)
FUJITA Nobuya Nara Medical Univ. ENT Depart., assistant doctor, 医学部, 助手 (20165385)
TANAKA Osamu Nara Medical Univ. ENT Depart., assistant Prof., 医学部, 講師 (30142384)
太田 和博 奈良県立医科大学, 医学部耳鼻咽喉科, 助手 (80150598)
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| Project Period (FY) |
1987 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1989: ¥100,000 (Direct Cost: ¥100,000)
Fiscal Year 1988: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1987: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | rabbit / the whole body response / linear acceleration / optokinetic stimulation / sensory conflict / labyrinthectomy / parasympathetic nerve / motion sickness / 視覚刺激 / 心拍数 / 変動係数 / アドレナリン / 遊離脂肪酸 / 対軸方向刺激 / 血糖 |
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| Research Abstract |
To study neural mechanisms of motion sickness in rabbits, we examined the physiological and biochemical body responses by several kinds of vestibule-visual conflict (VVC) stimulation (Type 1, Type 2a, Type 2b) for 300sec. Vestibular stimulation (VES) was linear oscillatory acceleration (amplitude:50cm, frequency:0.29Hz or 0.14Hz, direction: X=longitudinal, Y=transverse, Z=vertical) and visual stimulation (VIS) was optokinetic stimulation (random dot pattern drum with uniform velocity). Type 1 VVC stimulation was VES with VIS, Type 2a was VES without visual input and Type 2b was VIS only. Main results were as follows; 1. Heart rates (HR) decreased and coefficient of variation of R-R interval (CV-RR) increased during longitudinal Type 2a. And after atropine injection or bilateral labyrinthectomy, the changes of HR and CV-RR vanished. 2. Whole body responses during Type 2b were smaller than during Type 2a. 3. On body responses during Type 1, there was much difference between each rabbit. These results suggested that the extent of body responses differred by type of VVC stimulation, and in particular linear acceleration affected vestibule-autonomic reflex probably otolith-parasympathetic nerve reflex. Our results that the change of body responses decreased if VVC stimulation dissolved supported sensory conflict theory.
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