| Project/Area Number |
62570941
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SHIBUYA Masayuki Faculty of Pharmaceutical Sciences, the University of Tokushima, 薬学部, 教授 (40027066)
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| Co-Investigator(Kenkyū-buntansha) |
TOYOOKA Kouhei (Assistan : Faculty of Pharmaceutical Sciences, the University of Tokushima, 薬学部, 助手 (90145011)
KUBOTA Seiju (President) : The University of Tokushima, 学長 (60035532)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1988: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1987: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Carzinophilin / Azinomycin / Neocarzinostatin / Antibiotic / Chemical Structure / Chemical Synthesis / DNAの切断 / 紫外線 / 抗腫瘍活性 / NDAの切断 / 絶対配置 |
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| Research Abstract |
Carzinophilin (CZ) and Neocarzinostatin Chromophore (NCS-Chr) are well known antitumor antibiotics, the structures of which are still not established. We predicted that cz is the same compound as Azinomycin which has been isolated by the research group of SS-Pharm, Co., and confirmed that by the synthesis of its left moiety. For the total synthesis of CZ (Azinomycin), we established the effective synthetic methods. In relation to the in vivo antitumor mechanisms of NCS-Chr, we synthesized oligo-N-methyl pyrrole derivatives by use of novel and efficient method. The DNA-cleaving activity of synthetic compounds under photo irradiation was investigated. Other heterocyclic compounds such as AK-toxin and some thiadiazoles were synthesized in order to search effective antitumor compounds. The test of bioactivities of synthetic compounds is under progress.
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