| Budget Amount *help |
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1988: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1987: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Research Abstract |
1. Mono- and di-glucosides of dioxabicyclooctane lignans, pinoresinol, medioresinol and syringaresinol, were isolated from Eucommiae Cortex and Acanthopanax senticosus Stem Bark, which have been used as a restorative tonic. The structureinhibitory activity relationships of the aglycone and its glucosides on cyclic AMP phosphodiesterase inhibition were discussed. The order of inhibitory effect was diglucoside aglycone>monoglucoside. Syringaresinol di-O-beta-D-glucoside, which shows trong inhibitory activity, exhibited the prolonging effect on swimming exercise in rats.
2. l-Sesamin isolated from Hydrocotgle sibthorpioides showed the blood coagulation activity. The related lignans, d-sesamin, pinoresinol, isohinokinin, pluviatolide, arctigenin and matairesinol, did not show the activity.
3. Aqueous extract of stem part of Caulis Trachelospermi, which has been used for treatment of blood stagnant (oketsu), showed inhibitory activity of superoxide production and relaxant activity against histamine-induced contraction of tracheal muscles in guinea pig. It was shown that these activities depends on lignans, arctigenin, matairesinol, trachelogenin and nortrachelogenin, which are soluble in ether fraction. The glucosides did not show the activities.
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