| Project/Area Number |
62570971
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Physical pharmacy
|
|---|
| Research Institution | Josai University |
|---|
Principal Investigator |
SUGIBAYASHI Kenji Josai University, 薬学部, 講師 (00105834)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HATANAKA Tomomi Josai University, 薬学部, 助手 (10198749)
NATSUME Hideshi Josai University, 薬学部, 助手 (40180533)
JUNI Kazuhiko Josai University, 薬学部, 助教授 (80111178)
|
|---|
| Project Period (FY) |
1987 – 1988
|
| Project Status |
Completed (Fiscal Year 1988)
|
| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1988: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1987: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
|---|
| Keywords | oily drug carrier / blood vessel-embolism / cisplatin / targeted delivery system / シスプラチン / 癌部位集積性 / 薬物担体 / 粘性油性製剤 |
|---|
| Research Abstract |
Findings and results obtained for utilities of oily drug carriers with blood vessel-embolism capacity are follows:
(1) Oleic acid (OA) and ethyl oleate (EO) were selected as oily drug carriers and aluminum stearate and ethyl cellulose were added to enhance the blood vesselembolism capacity to OA and EO, respectively.
(2) Visual microscopical observation of blood vessel-embolism capacity after intra-arterial infusion in the cheek pouch in hamsters suggested that embolism periods and sites could be modified by changing the viscosity of the oily carriers.
(3) Retainment of oils after intra-arterial infusion of viscous EO into the stomach, Kidney and liver in rats was increased by increasing the viscosity of the oily carriers. Percent retainment in the liver was most effective, followed by those in the stomach and kidney. When comparing viscous OA with viscous EO, the former showed higher retainment and was less safe.
(4) Similar retainment experiments after infusing cisplatin-entrapped viscous EO in rats which AH 272 cells were inoculated showed that the viscous EO and entrapped cisplatin significantly concentrated in the tumor sites of the liver.
(5) Cisplatin-entrapped viscous EO showed marked antitumor effect on the AH 272 bearing rats. The effects were higher than those of free cisplatin and cisplatin free viscous Eo. These results suggest that viscous oily drug carriers can be used as a targeted delivery system in cancer chemotherapy.
|
