| Project/Area Number |
62571017
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
医学一般
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| Research Institution | Nattional Institute of Health. |
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Principal Investigator |
KOBUNE Fumio Chief Investigator, National Institute of Health., 麻疹ウイルス部, 主任研究官 (80142644)
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| Co-Investigator(Kenkyū-buntansha) |
TANABAYASHI Kiyoshi Investigator, Department of Measles Virus.(N.I.H.), 麻疹ウイルス部, 研究員 (50197505)
CHINO Fumitoshi Director, Department of General Biologics Control(N.I.H.), 生物製剤管理部, 部長 (80072908)
SUGIURA Akira Director, Department of Measles Virus(N.I.H.), 麻疹ウイルス部, 部長 (80077172)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1988: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1987: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Febrile viral infection / Antipyretics / Rinderpest virus / 肝病変 / ウイルスの異常増殖 / 動物実験モデル / ウイルス感染症 / 発熱 / ウイルス増殖 |
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| Research Abstract |
Administration of acetylsalicylic acid or mefenamic acid during experimental infection of rabbits with a rabbit-adapted strain of rinderpest virus did not prevent initiation of the febrile response but significantly reduced the duration of fever. Suppression of fever had a markedly deleterious effect on the course of infection, resulting in an increased content of infectious virus in the mesenteric lymph nodes, increased mortality, and retarded recovery in animals that survived the infection. Histological lesions were mainly lymphocytic depletion in lymphoid organs and lymphoid necrosis in both rabbis treated with antipyretics and those left untreated, but damage was more pronounced in the former than in the latter.
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