| Project/Area Number |
62580073
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
家政学
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| Research Institution | Nara Saho Women's College |
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Principal Investigator |
GOTOH Hiroko Life Science Associate Proffessor, Nara Saho Women's College, 生活科学科, 助教授 (00167412)
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| Co-Investigator(Kenkyū-buntansha) |
長谷川 千鶴 奈良佐保女学院短期大学, 家政学科, 教授
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1988: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Niacine / Nicotinamide / Pregnancy / Malformation / NAD^+ / 抗催奇性 / 抗腫瘍性 / 妊娠障害 / 栄養障害 / ニコチン酸 |
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| Research Abstract |
This work was studied to know the mechanism of the preventeve and therapeutic effects of nicotinamide on the malformation or cancer furthermore,and to know the efficiency of this vitamin on other diseases. Niacin plays the important role in carbohydrate or amino acid metabolism and in other physiological function. Some metabolic disorderes may occur because of niacin deficiensy especially in gestational period, so the duration of gestation was divided into several groups, and the mice were treated with niacin deficient diet during that period.
When the pregnant mice were fed for 19days with that diet, the rate of pregnancy was significantly decreased(66.7%),and high incidence of malformed fetuses (cleft--palate)were yielded(11.5%). It is significant result that an abnormal pancreas was markedly observed (11/18:61%). From the microscopical examination, the degree of pancreatoid status was pararell to the progress of pregnancy.
The value of the determination of serum glucose was considerably fallen(56.9%). Administration of the high doses of nocotinamide for long time may be poisonous for pregnant mice.
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