| Project/Area Number |
62840015
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
有機化学一般
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| Research Institution | Gunma University |
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Principal Investigator |
MIGITA Toshihiko Faculty of Engineering, Gunma University, 工学部, 教授 (40008412)
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| Co-Investigator(Kenkyū-buntansha) |
SANO Hiroshi Faculty of Engineering, Gunma University, 工学部, 助手 (40162523)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1988: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1987: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Keywords | deoxygenation / acetylated sugar / deoxysugar / トリフェニルシラン |
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| Research Abstract |
Deoxygenation of sugars occupies a significant position in carbohydrate chemistry. Although there have been numerous methods for the deoxygenation via various intermediates, reports of satisfactory methods for the deoxygenation of acetylated sugars, which were often utilized in sugar chemistry, are rare. We have then investigated new efficient routes for the transformation of sugar compounds to deoxysugars.
1. Triphenylsilane is a good deoxygenating reagent for the transformation of acetylated sugars to deoxysugars. The deoxygenation has a advantage that the acetylated sugars can be deoxygenated without affecting the other functinalities such as acetals, since the reaction proceeds under neutral conditions.
2. p-bis(diphenylhydrosilyl)benzene is a excellent reducing reagent for the deoxygenation of acetylated sugars, since the deoxygenation proceeds completely with less amount of the reducing agent compared with the case of triphenylsilane. Furthermore, the resulting deoxysugars can be easily isolated from the reaction mixture, since the by-products derived from the reagent are high boiling compounds.
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