| Project/Area Number |
62870029
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
内科学一般
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| Research Institution | Osaka University |
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Principal Investigator |
KAMADA Takenobu Professor, Department of Medicine, Osaka University Medical School, 医学部, 教授 (80028399)
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| Co-Investigator(Kenkyū-buntansha) |
笠原 彰紀 大阪大学, 医学部附属病院, 医員
MATSUMURA Takakatsu Assistant professor Department of Medicine, Osaka University Medical School, 医学部, 助手 (90183615)
KAWANO Sunao Assistant professor Department of Medicine, Osaka University Medical School, 医学部, 助手 (60133138)
FUSAMOTO Hideyuki Assistant professor Department of Medicine, Osaka University Medical School, 医学部, 助手 (90124776)
SATO Nobuhiro Associate professor Department of Medicine, Osaka University Medical School, 医学部, 講師 (90028358)
MEREN Haruya Assistant professor Department of Medicine, Osaka University Medical School
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥22,000,000 (Direct Cost: ¥22,000,000)
Fiscal Year 1988: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 1987: ¥12,000,000 (Direct Cost: ¥12,000,000)
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| Keywords | Ultrasonic frequency-cepstrum analysis / Infrared light analysis / non-operative therapy for cancer / htperthermia / fiber bundle / ケプストラム解析 / 肝癌 |
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| Research Abstract |
The aim of this investigation is to develope a non-operative, hyperthermia system for cancer treatment with continuous monitoring of cancer tissue by ultrasonic frequency-cepstrum analysis and infra-red light analysis. For this purpose, we introduced a radio-frequency type hyperthermia system and monitored the tissue temperature by Cu-constantan thermocouple. Simultaneously, we developed (1) an infra-red monitoring system for tissue hemodynamics and tissue oxygenation using a thin optical fiber and 2) a ultrasonic frequency-cepstrum system for morphological analysis of hepatic lobules. The former enabled to estimate the oxygenation level of local tissue, thereby determining the local functional change following hyperthermic reaction. The latter was applied to chronic liver diseases including hepatocellular carcinoma, and afforded non-invasive, objective informations as to pathological changes of microstructures of hepatic tissue: cancer tissue showed a wide histogram of average distance of scatters in the liver, thereby differenciating the cancerous region from cirrhosis. Hyperthermia induced an increase of blood flow in normal tissue rather homogeneously, but quite heterogenously in the imjured tissues. Oxygenation level also changed heterogenously in the latter tissue, which resulted in tissue derangement and could be monitored by ultrasonic frequency-cepstrum analyzing system. The combination of the instrument for advanced cancers.
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