| Project/Area Number |
62870033
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
TAKISHIMA Tamotsu First Department of Internal Medicine, Professor, 医学部, 教授 (20004765)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Hiroshi First Department of Internal Medicine, Associate Prof., 医学部附属病院, 講師 (40133962)
YOSHIHIRO Kikuchi First Department of Internal Medicine, Assistant Prof., 医学部附属病院, 助手 (20195217)
YOSHIO Shimizu First Department of Internal Medicine, Assistant Prof., 医学部附属病院, 助手 (90005421)
HIDA Wataru First Department of Internal Medicine, Assistant Prof., 医学部附属病院, 助手 (10142944)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 1988: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1987: ¥8,500,000 (Direct Cost: ¥8,500,000)
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| Keywords | sleep apnea / 上気道抵抗 / デマンド型頤舌筋刺激装置 / 上気道閉塞 / 電気刺激 / デマンド型オトガイ舌筋刺激装置 |
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| Research Abstract |
1) Animal study: To investigate the possible effectiveness of Genioglossus muscle (GG) stimulation on upper airway resistance in six anesthetized dogs. The upper airway was isolated from the lower airway by transecting the cervical trachea and the pressure flow relationship of the upper aireay was obtained by applying constant negative pressure (5, 10 and 20 cm H_2O) to the proximal cut end of the trachea. Upper airway resistance (Rua) was significantly reduced by stimulation. below 50Hz Rua decreased markedly as frequency increased, but above 50Hz Rua approached a minimum value.
2) Clinical study: We examined the effects of percutaneous electrical stimulation of the GG muscle in patients with odstructive sleep apnea symdrome (OSAS) during sleep. Using an apnea demend-type stimulator which we have developed, submental electrical stimulation was triggered five seconds after onset of apnea, which was recorded by tracheal breathing sound, and was stopped immediately after breathing resumed or after ten seconds at the longest. With submental stimulation, the apnea index, longest apnea duration, and the number of times per hour that oxygen saturation dropped below 85% decreased significantly, compared to control nights. These findings suggest that the apnea demand-type stimulator may be a non-invasive and effective treatment for OSAS.
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