| Project/Area Number |
62870053
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Keio University |
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Principal Investigator |
TANISHITA Kazuo KEIO University, Dept of Mech. Eng., Associate Professor, 理工学部・電気工学科, 助教授 (10101776)
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| Co-Investigator(Kenkyū-buntansha) |
KIKKAWA Shoh Toho University, Dept. of Physics, Professor, 理学部・物理学科, 教授 (30075329)
IMANURA Yohji KEIO University, Medical School, Research Associate, 医学部・胸部外科, 助手 (10118911)
SOHMA Yasuhiro KEIO University, Medical School, Assistant Professor, 医学部・胸部外科, 専任講師 (40051437)
MINAMITANI Haruyuki KEIO University, Dept. of Electrical Eng., Professor, 理工学部・電気工学科, 教授 (70051779)
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥5,800,000 (Direct Cost: ¥5,800,000)
Fiscal Year 1988: ¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1987: ¥3,900,000 (Direct Cost: ¥3,900,000)
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| Keywords | Membrane oxygenator / CO_2 removal / ECCO_2R / High performance artificial lung |
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| Research Abstract |
Extracoporeal CO_2 removal (ECCO_2R) by a membrane lung appears to be a premising technique of respiratory support in the treatment of acute respiratory failure. CO_2 transfer performance in a membrane lung depends on both membrane and blood phase resistance. In the present study we have found out the way of improving CO_2 removal rate by means of microporous tubes materials offering negligible membrane resistance and various configuration of curved tubes reducing the blood phase resistance. CO_2 removal rate for various type of curved tubes was evaluated by ex vivo canine experiments and CO_2 removal efficiency went up to more than five times as large as that for straight tube. However, the membrane permeability of CO_2 was deteriorated by plasma leakage through pores. In order to evaluate the deterioration, the wettability of microporous membrane was measured by the capillarography method.
As a result of evaluating CO_2 removal rate we found the design features of the highly efficient CO_2 removal lung which could be successfully applied to ECCO_2R.
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