| Project/Area Number |
62870070
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| Research Category |
Grant-in-Aid for Developmental Scientific Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | University of Tokyo |
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Principal Investigator |
MASUDA Kanjiro University of Tokyo, School of Medicine, 医学部(病), 教授 (60010188)
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| Co-Investigator(Kenkyū-buntansha) |
小杉 正明 HOYA株式会社事業部学術課, 学術課長
OSHIKA Tetsuro University of Tokyo, School of Medicine, 医学部(病), 助手 (90194133)
ARAIE Makoto University of Tokyo, School of Medicine, 医学部(病), 講師 (00092122)
KOSUGI Masaaki Hoya Co.,Ltd.
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| Project Period (FY) |
1987 – 1988
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| Project Status |
Completed (Fiscal Year 1988)
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| Budget Amount *help |
¥24,800,000 (Direct Cost: ¥24,800,000)
Fiscal Year 1988: ¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1987: ¥19,800,000 (Direct Cost: ¥19,800,000)
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| Keywords | Cell-flare meter / Blood-barrier / Blood-aqueous barrier / anti-inflammatory drug / 手術術語炎症 / エンドトキシン / 炎症定量測定 / 術後炎症 / 非ステロイド点眼液 |
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| Research Abstract |
We deved a new instrument to measure the concentration of protein and unmber of cells in the anterior chamber of the eye, quantitatively and objectively. There was a close positive relationship between the photon count and the concentration of protein or the number of cells in vitro.
In the animal experiments, we could obtain the same results as these in vitro. From the human experiments, we got the results that there is an increase the protein in the anterior chamber as age increases and that there is a definite diurnal varition in the protein concentration. By using this insturment, we can judge the time course of the uveitis in patients, the effects of the drugs, the postoperative inflammation and the effects of anti-inflammatory drugs.
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