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Study on the reconstruction of the mandibular bone using Apatite porous block

Research Project

Project/Area Number 62870082
Research Category

Grant-in-Aid for Developmental Scientific Research

Allocation TypeSingle-year Grants
Research Field 外科・放射線系歯学
Research InstitutionYamanashi Medical College

Principal Investigator

OHNISHI Masatoshi  Yamanashi Medical College Professor, 医学部, 教授 (50014139)

Co-Investigator(Kenkyū-buntansha) OHTSUKI Kayoko  Yamanashi Medical College Lecturer, 医学部, 講師 (20185325)
ICHIZYOU Takashi  Tokyo Medical and Dental University Professor, 歯学部, 教授 (20013807)
Project Period (FY) 1987 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 1989: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1988: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1987: ¥2,500,000 (Direct Cost: ¥2,500,000)
KeywordsApatite porous block / Bioactive material / Osteo-Conduction / Mandibular reconstruction / Segmental resection / Bone scintigraphy / Bio-dynamics / Titanium reconstruction plate / 多孔体 / 再建用プレ-ト / 骨シンチグラフィ- / 下顎骨区域切除 / 下顎骨再建 / 下顎骨再建術 / 人工生体材料 / 骨補填材 / 下顎再建プレート / 下顎骨欠損 / 純チタン骨接合プレート
Research Abstract

Using animal experiments, the authors have been studying the morphological development of multiporous apatite blocks, and examining the bioaffinity of these blocks in vivo and the state of bone formation.
Based on the results of these animal experiments, clinical application of these blocks began in October 1980.
The aim of adapting apatite material as a substitute for the jaw bone can be roughly classified into two parts:(1) as a substitute shape, and (2) as a structural support. The former employs the method of planning the recovery and reformation of the bone shape when the extent of loss is small and the shape of the jaw bone needs to be transformed.
With this reconstruction method, after segmental resection, the lower jaw bone is left at both ends of the lost part, and in between them a bridge is made with the apatite. The bridge must therefore be fixed securely. Unfortunately, the apatite porous body is fragile, and the nature of the material does not allow it to be wired directly t … More o the mandibular bone. As a result, a frame structure support for the lower jaw bone is created by means of a metal plate reinforcement. For this purpose, we developed a metal plate made of titanium with a structure like that shown in. By screwing down the plate, the apatite block is firmly fixed in place, supported by the pressure welding of the bones from the front and rear, and the plate from outside and underneath.
The apatite bone substitute material as artificial living tissue is much easier to handle compared to the transplant of, for example, intestinal bone tissue or costa from living bone tissue for the reconstruction of the lower jaw bone. However, to obtain clinical results which equal reconstruction by living bone tissue using artificial living tissue material, a strict operation system and control are necessary where by maximum utility is achieved by fully considering the biodynamics of the material. For this purpose, it will be necessary to consider an operation that uses artificial bone in the same way as or more deeply than a bone transplant operation using living bone tissue. Less

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] 大西正俊: "下顎骨再建に対する人工材料-アパタイト多孔体ブロックについて-" JOHNS. 6. 173-180 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大西正俊: "人工骨アパタイトによる再建下顎骨の経過-特に架橋補填症例について-" 頭頸部腫瘍. 15. 119-124 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大西正俊: "人工顎骨-人工生体材料アパタイトによる下顎骨の再建" 耳鼻咽喉科・頭頸部外科. 60. 291-297 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大西正俊: "人工骨ハイドロキシアパタイトによる下顎骨の再建" 日本口腔外科学会雑誌. 34. 1042-1046 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大西正俊: "アパタイトセラミックスの外科的応用に関する問題点" 日本歯科医師会雑誌. 36. 803-810 (1983)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masatoshi Ohnishi: "The Clinical Applications of Hydroxyapatite Porous Blocks in Oral and Maxillofacial Surgery" 9 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大西正俊: "チタンの歯科利用" クインテッセンス社・東京, 55 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M.OHNISHI: "The Clinical Applications of Hydroxyapatite Porous Blocks in Oral and Maxillofacial Surgery." Bioceramics. 1. 102-117 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M.OHNISHI: "The Clinical Applications of Hydroxyapatite Porous Blocks in Oral and Maxillofacial Surgery." Bioceramics. 2. 108-117

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M.Ohnishi: "Clinical Observation of Mandihles Reconstructed with Apatite Porous Block -Report of Cases of Bridge Substitution-" Jpn.J.Oral.Maxillofac. 34(5). 1042-1046 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M.Ohnishi, Kayoko OHTSUKI, Eizi NAKAYAMA, Eizi NAKAMURA, Hideaki KANBAYASHI: "Clinical observation on the reconstructed mandibles used by apatite porous block - Cases of bridge substitution" Toukeibusyuyou. 15(2). 119-124 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M.Ohnishi: Jibi Inkoka, Tokeibu Geka. Igaku-Shoin Ltd Tokyo, 291-297 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大西正俊: "下顎骨再建による人工材料ーアパタイト多孔体ブロックについてー" JOHNS. 6. 173-180 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大西正俊: "人工骨アパタイトによる再建下顎骨の経過ー特に架橋補填症例についてー" 頭頸部腫瘍. 15. 119-124 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大西正俊: "人工顎骨ー人工生体材アパタイトによる下顎骨の再建" 耳鼻咽喉科・頭頸部外科. 60. 291-297 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大西正俊: "人工骨ハイドロキシアパタイトによる下顎骨の再建" 日本口腔外科学会雑誌. 34. 1042-1046 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大西正俊: "アパタイトセラミックスの外科的応用に関なる問題点" 日本歯科医師会雑誌. 36. 803-810 (1983)

    • Related Report
      1989 Annual Research Report
  • [Publications] Masatoshi Ohnishi: "The Clinical Applications of Hydroxyapatite Porous Blocks in Oral and Maxillofacial Surgery" 9 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大西正俊: "チタンの歯科利用" クインテッセンス出版,東京, 55 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大西正俊: 日本口腔外科学会雑誌. 34. 1042-1046 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 大西正俊: バイオセラミックスの開発と臨床 クインテッセンス出版. 141-144 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] 大西正俊: チタンの歯科利用 クインテッセンス出版. 261-266 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 大西正俊,大月佳代子,中山英二,中村英二,神林秀昭: 頭頚部腫瘍. 16. 119-124 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 神林秀昭,大西正俊,小〓誠,一條尚: 口腔病学会雑誌. 56. 204 (198)

    • Related Report
      1988 Annual Research Report
  • [Publications] 神林秀昭,小〓誠,一條尚,大西正俊: 第43回日本口腔科学会総会. (1989)

    • Related Report
      1988 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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