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Studies on environmental carcinogenesis in People's Republic of China.

Research Project

Project/Area Number 63042004
Research Category

Grant-in-Aid for Overseas Scientific Survey.

Allocation TypeSingle-year Grants
SectionSpecial Cancer Research
Research InstitutionNagoya University

Principal Investigator

AOKI Kunio  Nagoya University, School of Medicine, 医学部, 教授 (60073102)

青木 国雄 (1989)  名古屋大, 医, 教授

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Masayoshi  SRL Co. Ltd., 八王子研究所, 所長
ITO Yoshinori  Fujita-Gakuen Health University, School of Medicine, 医学部, 助教授 (50087665)
SASAKI Ryuichiro  Nagoya University, School of Medicine, 医学部, 助教授 (80131241)
TSUCHIHASHI Yasunari  Kyoto Prefectural University of Medicine, 助教授 (50106390)
KAWAI Keiichi  Kyoto Prefectural University of Medicine, 教授 (50079745)
Project Period (FY) 1987 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥16,100,000 (Direct Cost: ¥16,100,000)
Fiscal Year 1989: ¥8,000,000 (Direct Cost: ¥8,000,000)
Fiscal Year 1988: ¥8,100,000 (Direct Cost: ¥8,100,000)
KeywordsEpidemiological Study of Stomach Cancer / Epidemiological Study of Lung Cancer / Campylobacter Pylori Infection / Serum Beta-carotene / Screening of Lung Cancer
Research Abstract

1 . Stomach cancer (1) Salted pork, dried salted small fishes and vinagered noodle showed strong mutasgenieity. (2) Improving dietary habit in a high risk area, China, is associated with improving stomach mucosa in the high risk area. (3)The correlaton between campylobacter infection stomach cancer is now under study. (4) Regressive changes of cappillary of blood vessel in chronic inflammation of submucosa were found. (5) Resected tissues of stomach could be cultured out of body the specimens are under study. (6) New monoclonal antibody GLO13 is useful for diagnosis in China. (7) Positive association of changes in frequency of Green-yellow vegetable and changes in serum carotene for one year was observed. (8) Four thousands inhabitants measured serum beta -carotene in Japan are following up. (9) About 100 cases with chronic gastritis are treated by traditional herbs medicine in China. (10)A new method of methylen blue could be clarified extent and degree of intestinalisation of gastric mucosa in Japan. Intake of fruits inhibited progression of gastric intestinalisation. Meat intake promoted proliferation of parietal cells of stomach.
2 . Lung Cancer (1) Age at onset of lung cancer was younger Shenyang than in Kyoto. Squamous cell carcinoma for the younger age groups less than 39 was frequently observed in Japan and small cell carcinoma was in China. Adeno-cystic carcinoma was frequently found in Chinese lung cancer. Mass screening using sputum and chest indirect radiography showed a relatively high prevalence of lung cancer in Fusin, China. DNA quantitative diagnosis on cytologin specinems is now under study. (2) Case-control study on lung cancer was carried out the data of 100 cases and 200 controls were now under study.

Report

(1 results)
  • 1989 Final Research Report Summary
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] 吉見直己: "顕微画像解析法によるDNA定量と癌診断" 医学のあゆみ. 147. 593-595 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 土橋康成: "ヒト組織のBUdR in vitro標識法ー人工血液を用いて" 医学のあゆみ. 149. 619-622 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 林恵芝: "胃癌高、低率区居胃粘膜対幽門弯曲菌的感染及其与胃病的〓系" 中華腫瘤〓志. 11. 364-366 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 袁媛: "胃癌単克隆抗体GLー013対〓抗原的免疫電鏡分布観察" 中国医科大学学報. 19. 6-8 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 林恵芝: "胃癌高率区居民血清学検査〓〓観察及其与低率区者対比" 中国医科大学学報. 19. 37-39 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 白希文: "庄河、新民胃癌高、低率区志願者胃鏡検査的胃粘膜所見" 中国医科大学学報. 19. 40-42 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Suzuki,Sadao: "Changes in Serum Concentration of beta-carotene and Changes in the Dietary Intake Frequency of Green-yellow Vegetables among Healthy Male Inhabitants of Japan" Japanese Journal of Cancer Research. 81. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kawai,Keiichi: "Is Atrophic Gastritis or Intestinal Metaplasia Precancerous Condition of Gastric Cancer?" Epidemiology & Prevention of Cancer(eds.,R.Sasaki,K.Aoki).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sasaki,Ryuichiro: "The Relationship between Serum beta-carotene Level and Intake Frequency of Green-yellow Vegetables and Some Other Factors." Epidemiology & Prevention of Cancer(eds.,R.Sasaki,K.Aoki).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yoshimi, Naoki: "DNA Measurement and Quantitative Diagnosis for Cancer Using Microscopic Image Analysis." Igaku no Ayumi. 147. 593-595 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tsuchihashi, Yasunari: "In Vitro BUdR-labelling of Human Specimens Using Perfluorotributylamine Emulsion" Igaku no Ayumi. 149. 619-622 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Lin Hui-zhi: "Campylobacter Pyloridis (CP) Infection of Gastric Mucosa in the High and Low Risk Areas of Gastric Cancer in Liaoning Province." Chinease Journal of Cancer. 11. 364-366 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yuan Yuan: "The Ultrastructural Distribution of the Antigen Associated with Monoclonal Antibody(GL-013) in the Gastric Cancer" Journal of China Medical University. 19. 6-8 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Lin Hui-zhi: "Change of Dietary Habits in Inhabitances and Serum Carotenoids Levels in High Risk Area of Stomach Cancer" Journal of China Medical University. 19. 37-39 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Bai Xiwen: "Gastroscopical Findings of Gastric Mucosa in the Volunteers at Zhuanghe and Xinmin Counties with High and Low Incidence of Gastric Cancer" Journal of China Medical University. 19. 40-42 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Suzuki, Sadao: "Changes in Serum Concentration of beta-carotene and Changes in the Dietary Intake Frequency of Green-yellow Vegetables among Healthy Male Inhabitants of Japan" Japanese Journal of Cancer Research. 81. (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kawai, Keiichi: "Is Atrophic Gastritis or Intestinal Metaplasia Precancerous Condition of Gastric Cancer?" Epidemiology & Prevention of Cancer (eds., R. Sasaki, K. Aoki).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sasaki, Ryuichiro: "The Relationship between Serum beta-carotene Level and Intake Frequency of Green-yellow Vegetables and Some Other Factors." Epidemiology & Prevention of Cancer (eds., R. Sasaki, K. Aoki).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary

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Published: 1988-04-01   Modified: 2016-04-21  

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