| Project/Area Number |
63042015
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| Research Category |
Grant-in-Aid for Overseas Scientific Survey.
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | Aichi Cancer Center |
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Principal Investigator |
TOMINAGA Suketami Acting Director, Chief of Division of Epidemiology, Aichi Cancer Center Research Institute, 副所長兼疫学部長 (30124530)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHITA Hidetsuru Professor and Chief, Department of Community Environmental Science The Institute, 地域環境衛生部, 部長 (30124407)
SHIMIZU Hiroyuki Professor and Chairman, Department of Public Health, Gifu University, School of, 医学部公衆衛生学教室, 教授 (90073139)
MATSUKI Hideaki Assistant Professor, Department of Public Health, Tokai University, School of Me, 医学部公衆衛生学教室, 助教授 (90096264)
MORI Toru Chief, Division of Epidemiology, Research Institute of Tuberculosis, Japan Anti-, 第2研究部部長
TSUCHIYA Eiju Researcher, Division of Pathology, Cancer Research Institute, 病理学, 研究員 (00072314)
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| Project Period (FY) |
1984 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 1989: ¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 1988: ¥7,000,000 (Direct Cost: ¥7,000,000)
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| Keywords | Hong Kong / Female lung cancer / Indoor pollution / Passive smoking / Epidemiology / Etiology / Pathology / Adenocarcinoma |
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| Research Abstract |
Lung cancer mortality and incidence are very high in females of Hong Kong although their smoking rate is relatively low. In order to elucidate etiological factors and pathological characteristics of lung cancer in females of Hong Kong, a series of comparative epidemiological and pathological studies were conducted in Hong Kong and Japan.
1) Epidemiological surveys on indoor air pollution
Exposure to indoor air pollution including passive smoking was estimated from a questionnaire survey on about 300 children and their mothers, measurements of personal exposure to NO_2 and hydroxy-proline concentration in the urine. Similar surveys were conducted in Tokyo to compare the results in Hong Kong and Japan.
The questionnaire survey revealed that the frequency of respiratory symptoms in both children and mothers in Hong Kong was about 10 times higher than that in Japan. However, the level of personal exposure to NO_2 and the concentration of hydroxy-proline in the urine were not much different between Hong Kong and Japan. The level of indoor air pollution in homes of Hong Kong was directly measured by using a low-volume air sampler. The concentrations of suspended particulate matters and aromatic hydrocarbon carcinogens were not much different between the two countries. Falling bacteria and fungi were collected, but their values were also about the same between Hong Kong and Japan.
2) Pathological studies
Histo-pathological features of surgically resected lung cancer cases in females were compared between Hong Kong and Japan and it was found that the central type lung cancer was much more common in Hong Kong cases than in Japanese cases.
3) Studies on various metals and other substances deposited in the lung tissue
To estimate the level of cumulative exposure to indoor and outdoor air pollution objectively, concentrations of various metals deposited in the lung tissue were measured, but their results were not much different between Hong Kong cases and Japanese cases.
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