| Project/Area Number |
63044017
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| Research Category |
Grant-in-Aid for Overseas Scientific Survey.
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Institution | Department of Public Health, Faculty of Medicine, Kyoto University (1989)
Tohoku University (1988) |
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Principal Investigator |
IKEDA Masayuki Department of Public Health, Faculty of Medicine, Kyoto University, 医学部, 教授 (00025579)
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| Co-Investigator(Kenkyū-buntansha) |
金 淬 中国預防医学科学院, 労働衛生職業病研究所, 副所長
劉 世傑 北京医科大学, 公共衛生学, 名誉教授
TAKEUCHI Yasuhiro Department of Hygiene, Nagoya University School of Medicine, 教授 (90022805)
NAKATSUKA Haruo Department of Environmental Health, Tohoku University School of Medicine, 助手 (70164225)
WATANABE Takao Miyagi University of Education, 助教授 (20004608)
LIU Shi-jie Beijing Medical University School of Public Health
JIN Chui Institute of Occupational Medicine
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| Project Period (FY) |
1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 1989: ¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1988: ¥5,000,000 (Direct Cost: ¥5,000,000)
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| Keywords | Toluene / Organic solvents / Dose-response relationship / Urinary metabolites / CNS-depressive effect / Subjective symptom |
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| Research Abstract |
The dose-response relationship was investigated among 1131 toluene-exposed Chinese workers (of both sexes) in comparison with 548 non-exposed peers. The intensity of exposure to toluene was monitored by means of diffusive sampling followed by CS_2 extraction and capillary gaschromatographic analysis. Possible effects were measured by questionnaires on subjective symptoms during the work and in the recent 3 month period, and by conventional hematology and serum biochemistry. Analysis for toluene metabolites in end-of-shift urine samples was also carried out. The urinary metabolite concentrations increased as a linear function of the exposure intensity (up to ca. 500 ppm as TWA), suggesting the validity of the exposure measurements conducted. Changes in hematology and in serum biochemistry among the exposed workers were fragmental with no systematic biomedical significance as compared with the nonexposed subjects. In contrast, the subjective symptoms were more frequently complained among the exposed than the controls, and such elevation in frequency was statistically significant and dose-related in the symptoms such as 'headache', 'heaviness in head' and 'floating sensation during work'.
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