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Dose-response relationship in toluene-exposed workers

Research Project

Project/Area Number 63044017
Research Category

Grant-in-Aid for Overseas Scientific Survey.

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionDepartment of Public Health, Faculty of Medicine, Kyoto University (1989)
Tohoku University (1988)

Principal Investigator

IKEDA Masayuki  Department of Public Health, Faculty of Medicine, Kyoto University, 医学部, 教授 (00025579)

Co-Investigator(Kenkyū-buntansha) 金 淬  中国預防医学科学院, 労働衛生職業病研究所, 副所長
劉 世傑  北京医科大学, 公共衛生学, 名誉教授
TAKEUCHI Yasuhiro  Department of Hygiene, Nagoya University School of Medicine, 教授 (90022805)
NAKATSUKA Haruo  Department of Environmental Health, Tohoku University School of Medicine, 助手 (70164225)
WATANABE Takao  Miyagi University of Education, 助教授 (20004608)
LIU Shi-jie  Beijing Medical University School of Public Health
JIN Chui  Institute of Occupational Medicine
Project Period (FY) 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥11,000,000 (Direct Cost: ¥11,000,000)
Fiscal Year 1989: ¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1988: ¥5,000,000 (Direct Cost: ¥5,000,000)
KeywordsToluene / Organic solvents / Dose-response relationship / Urinary metabolites / CNS-depressive effect / Subjective symptom
Research Abstract

The dose-response relationship was investigated among 1131 toluene-exposed Chinese workers (of both sexes) in comparison with 548 non-exposed peers. The intensity of exposure to toluene was monitored by means of diffusive sampling followed by CS_2 extraction and capillary gaschromatographic analysis. Possible effects were measured by questionnaires on subjective symptoms during the work and in the recent 3 month period, and by conventional hematology and serum biochemistry. Analysis for toluene metabolites in end-of-shift urine samples was also carried out. The urinary metabolite concentrations increased as a linear function of the exposure intensity (up to ca. 500 ppm as TWA), suggesting the validity of the exposure measurements conducted. Changes in hematology and in serum biochemistry among the exposed workers were fragmental with no systematic biomedical significance as compared with the nonexposed subjects. In contrast, the subjective symptoms were more frequently complained among the exposed than the controls, and such elevation in frequency was statistically significant and dose-related in the symptoms such as 'headache', 'heaviness in head' and 'floating sensation during work'.

Report

(1 results)
  • 1989 Final Research Report Summary
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 池田正之,渡辺孝男,中塚晴夫 他: "トルエン曝露労働者における用量ー作用関係"

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 井上修,清治利則,渡辺孝男 他: "中国人におけるトルエン曝露と尿中馬尿酸排泄の量的対応"

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ikeda, M. et al.: "Dose-reponse relationships among toluene-exposed workers"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Inoue, O. et al.: "Correlation between exposure to toluene and urinary excretion of hippuric acid among Chinese workers"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary

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Published: 1988-04-01   Modified: 2016-04-21  

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